Desonate (desonide) prescription available online 

If you are suffering from eczema, dermatitis, or other skin conditions, Desonate (desonide) can help. Get a new prescription or refill of Desonate from a board-certified doctor online.

Book an appointment

Medication services available for adults and kids (3+)

Top quality, board-certified doctors

Insurance accepted, but not required

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and our prescription discount card.

About Desonate (desonide)

Desonate is a type of topical corticosteroid that effectively treats skin rashes and irritations by reducing inflammation. Like other topical corticosteroids, it is commonly used to treat dermatitis, eczema, and rashes.

Desonate is a prescription-only medication available in various brand names such as DesOwen, DesRx, Tridesilon, and Verdeso, as well as a generic formulation called desonide.

If you are prescribed Desonate cream, it is crucial to follow the specific instructions provided in your prescription, which may vary based on the formulation and dosage you are prescribed. To ensure that your skin condition is fully treated, it is essential to complete the full course of topical corticosteroids, even if your symptoms improve.

Desonate uses

Desonate has several FDA-approved uses, but it can also be prescribed off-label for other conditions. Your doctor may prescribe it for various common reasons, and there is a possibility that they may also prescribe it for other reasons not listed below. If you have any concerns or questions regarding the medication prescribed, consult your online doctor or pharmacist.

Desonate side effects

  • Desonate's associated side effects are typically mild and mainly associated with skin irritation. Common side effects of Desonate can include:

    • Skin irritation

    • Skin changes (pimples, stretch marks, slow healing, hair growth)

    • Skin color changes

    Other side effects, which are less common but might be more severe, could include:

    • Changes in eyesight, eye pain, or eye irritation

    • Signs of high blood sugar like confusion, feeling sleep, unusual thirst or hunger

    • Signs of weak adrenal gland like severe upset stomach, severe dizziness or passing out, muscle weakness

    • Mood changes

    Seek emergency medical attention if you experience a very serious allergic reaction. You should call your doctor for medical advice about side effects or if you develop any other new or concerning symptoms. Use of Desonate in young children should be based on the severity of skin issues, and the smallest amount used for the shortest period of time is advised.

How to take Desonate

When you receive your Desonate prescription, your pharmacist will provide you with detailed instructions on how to use it. Desonate can be found in a variety of forms such as cream, gel, liquid, ointment, foam, or lotion.

It is crucial to read and follow the instructions on your prescription label carefully. In case of any questions or concerns, you can contact your doctor or pharmacy. Remember that this drug is not meant to be taken by mouth but only applied to your skin. Keep it away from your eyes, nose, and mouth.

As Desonate is available in different forms and doses, it is essential to adhere to the specific instructions mentioned in your prescription. Generally, it is recommended to apply a thin layer 2-3 times a day. Also, make sure to wash your hands before and after each use as per the specific instructions given to you.

What to avoid while taking Desonate

It appears that Desonate does not have any known possible drug interactions that require complete avoidance or alternative treatments. However, it is important to consult with your doctor or pharmacist before making any changes to your current medication regimen. Always tell your doctor about any medication you take, including supplements, herbal remedies, and over-the-counter drugs.

It is important to clean the affected part of your skin before use when taking Desonate. 

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Desonate.

Medication alternatives to Desonate

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another topical corticosteroid or an anti-inflammatory cream in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Desonate prescription FAQs

  • How much does Desonate cost?

    Desonide cream, the generic for Desonate, costs around $15 for a tube. You can find the lowest price at nearby pharmacies and save up to 80% on prescriptions as a PlushCare member with our in-app Rx Price Finder and prescription discount card.

  • How can I refill my Desonate prescription?

    Desonate is only available by prescription, so you can book an appointment with one of our board-certified doctors to get a refill on your prescription online. Your prescription will then be sent to your local pharmacy for pickup if you qualify.

  • Who should not take Desonate?

    Do not take Desonate if you are allergic to Desonate, have skin infections or other infections, or have diabetes.

  • What happens if I miss a dose of Desonate?

    If it is close to your time for your next dose, skip the missed dose and go back to your normal time. Never double dose or put on extra doses.

  • What happens if I take too much Desonate?

    If you think you have taken too much corticosteroid medication, call your doctor for medical advice or call your local poison control center immediately.

  • What is desonide cream used for?

    Desonide cream is used for skin conditions like rashes, dermatitis, and eczema.

  • Is desonide cream safe for face?

    Do not put desonide cream on your face, underarms, or groin area unless told to do so by your doctor.

  • Is desonide a strong steroid?

    Yes, desonide is a prescription-only strong steroid cream.

  • How quickly does desonide work?

    Desonide works quickly after being applied to the skin to reduce inflammation, redness, and itching.

  • Is Desonate generic?

    Desonide is the generic formula for Desonate.

3 simple steps to request your Desonate prescription today

Step 1

Book a Desonate prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your clinician regarding your Desonate prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Desonate prescription.

We can send prescriptions to any local pharmacy.

Desonate prescription pricing details

How pricing works

To get a new or refill on your Desonate prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.