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Invokamet (canagliflozin/metformin)
Chronic Care Diabetes Invokamet
Chronic Care Diabetes Invokamet

Invokamet (canagliflozin/ metformin) prescription available online

If you are suffering from type 2 diabetes, Invokamet (canagliflozin/ metformin) can help. Get a new prescription or refill of Invokamet from a board-certified doctor online*

Helps lower blood sugar Effective medication to treat type 2 diabetes* Request Invokamet in as little as 15 minutes, with or without insurance*
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*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card. Plushcare doctors cannot treat all cases of diabetes. Sometimes, in-person or specialist treatment via endocrinologists may be necessary. If that is the case, our doctors will guide you to those options with resources and referrals. 
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About Invokamet (canagliflozin and metformin)

Invokamet is a combination of two diabetes medications, an SGLT2 inhibitor called canagliflozin, and a biguanide called metformin. Canagliflozin encourages the kidneys to excrete more sugar through the urine, which lowers blood sugar. Metformin reduces the amount of sugar released from the liver and helps increase the amount of sugar absorbed from the bloodstream (decreasing insulin resistance). 

Invokamet is indicated to treat include type 2 diabetes and is available only by prescription. It is available in a generic formulation as well as under different brand names, including canagliflozin-metformin.

Invokamet may be prescribed as an extended-release tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Invokamet, be sure to take it as prescribed unless your doctor specifically tells you to stop. If you don’t, the medication may not adequately treat your type 2 diabetes.

Invokamet uses

Invokamet is FDA approved to treat type 2 diabetes, a chronic condition in which consistently high blood sugar leads to insulin resistance and further complications.

Type 2 diabetes mellitus

Invokamet is FDA-approved to treat type 2 diabetes mellitus. Invokamet helps lower blood sugar, which can help prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.

Invokamet is not recommended for the treatment of type 1 diabetes or diabetic ketoacidosis.

Invokamet side effects

The side effects associated with taking Invokamet are typically mild. Most Invokamet side effects are associated with gastrointestinal discomfort. Invokamet has some common side effects. They may include:

  • Gas, stomach pain, or indigestion

  • Urinating more than usual

  • Headache or weakness


If you experience stomach upset after taking your medication for several days, it’s important to contact your doctor right away as this can be a sign of something more serious such as metformin-associated lactic acidosis.

Other side effects, which are less common but might be more severe, could include:

  • Urinary tract infection

  • Groin yeast infections 

  • Lactic acidosis 

  • Skin gangrene or other severe skin infections 

  • High potassium levels (muscle weakness, chest pain, irregular heartbeat)

  • New pain, tenderness, or sores in your legs or feet


Talk to your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. Call 911 right away if any severe symptoms develop. Invokamet is not approved in patients under the age of 18.

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How to take Invokamet

Your pharmacist will provide you with instructions on how to take your Invokamet prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Invokamet can come in different forms and doses, so be sure to follow the specific instructions on your prescription. When taking Invokamet XR, patients will generally take two pills once daily per a doctor’s prescription. If you're taking regular Invokamet, you'll be prescribed to take one pill twice daily or as directed by your doctor.

Invokamet and Invokamet XR both come in four different strengths, including:

  • 50 mg/500 mg

  • 150 mg/500 mg

  • 50 mg/1000 mg

  • 150 mg/1000 mg

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What to avoid while taking Invokamet

Invokamet has many possible drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with Invokamet include:

  • Metformin

  • Gymnema

  • Digoxin

  • Rifampin

  • Ritonavir

  • Seizure medications


Ask your doctor for medical advice before drinking alcohol. Alcohol can exacerbate the effects of metformin on lactate metabolism, which can increase the risk of lactic acidosis. Excessive alcohol intake may also increase the risk of hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar) in patients with diabetes.

Medication alternatives to Invokamet

If your healthcare provider prefers to put you on another treatment altogether, they may suggest other SGLT2 inhibitors or diabetes medications in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Type 2 diabetes mellitus

Jardiance (empagliflozin) Lantus (insulin glargine) Glyxambi (empagliflozin linagliptin) Soliqua (insulin) Trulicity®

End-stage kidney disease

Farxiga (dapagliflozin) Jardiance (empagliflozin)

Invokamet prescription FAQs

How much does Invokamet cost?

Depending on your pharmacy, Invokamet typically costs around $640 for a supply of sixty 150 mg/5000 mg tablets without insurance. Fortunately, generic alternatives, such as canagliflozin and metformin, may offer an affordable alternative. Our prescription discount card helps members save up to 80% on prescriptions.

How can I refill my Invokamet prescription?

To refill your Invokamet prescription, book a virtual appointment with one of our top rated board-certified primary care doctors. After a qualifying evaluation, your prescription may be sent to your local pharmacy for pickup.

Who should not take Invokamet?

To make sure Invokamet is safe for you, tell your doctor if you have:

  • Cardiovascular disease or heart failure

  • Diabetic foot ulcers

  • Circulation problems in your legs or feet

  • Liver or kidney disease

  • Low levels of vitamin B12

  • Urinary tract infections or other bladder infections

  • Peripheral vascular disease

What happens if I miss a dose of Invokamet?

If you miss a dose of Invokamet, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

What happens if I take too much Invokamet?

If you've taken too much Invokamet, seek medical attention immediately by calling 911 or contact your local poison control center. Taking too much Invokamet can lead to extremely low blood sugar (severe hypoglycemia).

How does Invokamet work?

Invokamet combines canagliflozin and metformin to improve glycemic control and support the body's response to natural insulin. It helps patients remove sugar through their urine and reduce the amount released by their liver, among other benefits. 

What are the benefits of Invokamet?

Invokamet helps control blood sugar levels in adults with type 2 diabetes mellitus, which can prevent kidney damage, nerve-related issues, and blindness, among other complications.

Is Invokamet the same as metformin?

No, Invokamet contains metformin but also includes the SGLT2 inhibitor called canagliflozin. Both medications are used to treat type 2 diabetes by lowering blood sugar. However, canagliflozin increases the amount of sugar passed out of the body through urine, while metformin reduces the absorption of sugar from the intestines. Combined, they work better than each other by themselves. 

What is Invokamet used to treat?

Invokamet is used to treat type 2 diabetes mellitus.

What type of drug is Invokamet?

Invokamet is a combination pill containing both a sodium-glucose cotransporter-2 (SGLT2) inhibitor and a biguanide.

3 simple steps to request your Invokamet prescription today

How It Works Step 1
Step 1

Book an Invokamet prescription request appointment.

Book a same day appointment from anywhere.
How It Works Step 2
Step 2

Talk to your medical provider regarding your Invokamet prescription.

Visit with a doctor on your smartphone or computer.
How It Works Step 3
Step 3

Pick up your Invokamet prescription, if provided.

We can send prescriptions to any local pharmacy.

Invokamet prescription pricing details

To get a new or refill on your Invokamet prescription, join our monthly membership and get discounted visits.

30 days of free membership

  • Same-day appointments 7 days a week
  • Unlimited messages with your Care Team
  • Prescription discount card to save up to 80%
  • Exclusive discounts on lab tests
  • Free memberships for your family
  • Cancel anytime

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Paying without insurance

Membership

$19.99

First month free

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Visits

$129

Visit price without insurance

Initial visits are $129.
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*If we're unable to treat you, we'll provide a full refund. Please note that any medication or lab work costs are not included. Please refer to our refund policy for additional information.

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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.