When taken as prescribed, antihistamines are generally well tolerated. However, they can still cause some side effects.
The more common side effects of antihistamines include:
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Confusion
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Blurry vision
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Dry mouth
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Drowsiness
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Vomiting
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Nausea
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Dizziness
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Moody behavior
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Trouble urinating
In rare cases, antihistamines may cause serious side effects. These can include: -
Delirium
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Euphoria
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Reduced coordination
According to peer-reviewed studies, H-1 antihistamines typically cause more noticeable side effects. These side effects are more common with first-generation antihistamines. Second-generation antihistamines have limited side effects.
A dry mouth is one of the most well-recorded side effects. Some patients also experience tinnitus and dizziness. With increased dosages, poor coordination and euphoria can happen. Delirium is a probable side effect at much higher doses.
H-2 receptors tend to be well-tolerated. But, they can still cause side effects. Gastrointestinal changes, confusion, dizziness, and fatigue can occur. One particular drug in this category that could trigger various side effects is cimetidine. It can lead to enlarged breast tissue in men (gynecomastia) and milky nipple discharge (galactorrhea) in women.