Anafranil (Clomipramine) Prescriptions Available Online Today

If you suffer from obsessive-compulsive disorder, clomipramine can help. Get a new prescription or refill of clomipramine today from a board-certified doctor online.*

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Comprehensive care for mental health

Available as a capsule

FDA-approved to treat OCD

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card. Not all cases of OCD can be safely managed by telehealth or primary care physicians. If our Plushcare doctors cannot treat your OCD directly, they will guide you with resources and referrals to specialists (psychiatrists) and in-person care options.

About clomipramine 

Clomipramine is a tricyclic antidepressant that restores the balance of certain substances, such as serotonin, in the brain.

Clomipramine is used to treat obsessive-compulsive disorder (OCD) and is available only by prescription. It is also available as a brand name medication, Anafranil.

Clomipramine may be prescribed as a capsule. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed clomipramine, be sure to take it as prescribed in order for it to reach its full potential of benefit. 

Clomipramine uses

Clomipramine is only FDA-approved to treat OCD, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for the following reasons.

It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. Ask your online doctor if you have questions about why a medication is prescribed.

  • Obsessive-compulsive disorder

    Clomipramine is FDA-approved for treating OCD. It helps decrease unwanted or recurrent thoughts (obsessions) and reduce the urge to perform repeated tasks (compulsions).

  • Other mental health conditions

    Clomipramine may also be prescribed off-label to treat depression, anxiety, panic disorder, and panic attacks.

Clomipramine side effects

The side effects associated with taking clomipramine are typically mild, common ones including:

    • Feeling dizzy, drowsy, or tired

    • Tremors or jerking muscle movements

    • Changes in appetite or weight

    • Change in libido 

    • Erectile dysfunction 

    Other side effects, which are less common but might be more severe, could include:

    • Low sodium levels

    • Blurred vision

    • Urinary retention or trouble urinating

    • Worsening depression or suicidal thoughts

    Ask your doctor for medical advice if you notice any adverse reactions, or if you develop any other new or concerning symptoms. In rare cases, antidepressant drugs can cause serotonin syndrome, a potentially life-threatening condition in which too much serotonin is present in your system. This usually only occurs if you are taking drugs that also raise serotonin levels. Symptoms can include anxiety, agitation, abdominal pain, and skin flushing.

    The use of clomipramine in children younger than under age 10 is not advised.

How to take clomipramine

Your pharmacist will provide you with instructions on how to take your clomipramine prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Clomipramine can come in different forms and doses, so be sure to follow the specific instructions on your prescription. For adults and young adults with obsessive-compulsive disorder, the starting dose is typically 25 mg orally once daily. The maintenance dose may be increased to 100 mg orally once daily.

Do not stop taking clomipramine without your doctor's recommendation. Clomipramine withdrawal may lead to withdrawal symptoms such as dizziness, nausea, vomiting, and headache.

What to avoid while taking Clomipramine

Clomipramine has many possible drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with clomipramine include:

  • Other drugs that cause drowsiness, including sleeping pills, muscle relaxers, and opioid medication

  • Tricyclic antidepressants and monoamine oxidase inhibitors

  • Anti-seizure medication

Avoid drinking alcohol while taking clomipramine, as alcohol may lead to an increased risk of adverse reactions. Tell your doctor immediately if you experience uneven heartbeats, unusual tiredness, confusion, or lightheadedness.

Medication alternatives to clomipramine

If your healthcare provider prefers to put you on another treatment, they may suggest other tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs) in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

Clomipramine prescription FAQs

  • How much does clomipramine cost?

    Depending on your pharmacy, clomipramine costs around $25 for thirty 50 mg capsules without insurance. Clomipramine is a generic medication, and brand names may cost more but offer no increased medical benefit.

  • How can I refill my clomipramine prescription?

    Book a virtual appointment with a board-certified PlushCare doctor to refill your Anafranil prescription. After reviewing your symptoms and medical history, your doctor can send an electronic prescription to your local pharmacy, if deemed appropriate.

  • Who should not take clomipramine?

    Avoid taking clomipramine if you have certain medical conditions, such as:

  • What is the best time to take clomipramine?

    Taking clomipramine in the evening with your last meal is best to lessen drowsiness during the day.

  • Does clomipramine affect memory?

    Yes, clomipramine may rarely cause side effects such as memory impairment.

  • What happens if you drink alcohol with clomipramine?

    Drinking alcohol with Anafranil may worsen the side effects of the medication, such as dizziness, unusual tiredness, trouble sleeping, and poor concentration.

  • What happens if I miss a dose of clomipramine?

    If you miss a dose of clomipramine, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much clomipramine?

    If you've taken too much Anafranil, contact your doctor immediately or call your local poison control center. An overdose of Anafranil can be fatal.

3 simple steps to request your clomipramine prescription today 

Step 1

Book a clomipramine prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your clomipramine prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your clomipramine prescription, if provided.

We can send prescriptions to any local pharmacy.

Clomipramine prescription pricing details

How pricing works

To get a new or refill on your clomipramine prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.