Zanaflex (Tizanidine) prescription available online 

If you are suffering from muscle spasms caused by specific health conditions, Zanaflex can help. Get a new prescription or refill of Zanaflex today from a board-certified doctor online.*

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FDA-Approved Muscle Relaxant

Ease muscle spasms and impulses

Available for short term treatment

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Zanaflex 

Zanaflex is considered a skeletal muscle relaxant, which functions by inhibiting certain nerve impulses. These nerve impulses are directly related to the sensation of pain. The body sends these nerve impulses to the brain, which then results in the feeling of pain. By blocking these impulses, pain from multiple sclerosis, spinal cord injury, and several other conditions can be effectively reduced. Like any muscle relaxant, this medication can only be used for short-term muscle pain and spasms. It is ineffective against long-term treatment requirements because it can cause adverse effects if you take it for too long. This is why you should follow your doctor's instructions carefully, as misuse of the drug can lead to withdrawal symptoms and a greater risk of drug interactions.

Some conditions that Zanaflex is known to treat include muscle pain due to injuries or specific conditions, such as multiple sclerosis. Zanaflex is available only be prescription. It is available in a generic formulation under different brand names, including tizanidine.

Zanaflex may be prescribed as a capsule. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed Zanaflex, complete the entire course of the muscle relaxant unless your doctor specifically tells you to stop.

If you don’t complete your prescription, the muscle relaxant may not provide sufficient relief for your symptoms. You should also avoid taking more than prescribed, which can cause liver damage. Tell your doctor if you continue having pain in a sitting or lying position when using the medication. They may alter the dose or consider other drugs to treat your condition.

Zanaflex uses

There is one FDA-approved use for Zanaflex, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for the following reasons. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Pain And Muscle Spasms

    The FDA has approved using Zanaflex in the short-term treatment of muscle spasms and pains. Muscle relaxants benefit patients who experience muscle pain following a spinal cord injury. Those with multiple sclerosis may also benefit from Zanaflex and Zanaflex generic but must be careful about long-term use. If the patient suddenly stops using the medicine after a long period of time, they can develop withdrawal symptoms. These withdrawal symptoms can sometimes cause adverse effects, such as worsening the signs that they experience. Tell your doctor if you use other medications to help with pain management, as this can also reduce the risk of drug interactions.

Zanaflex side effects

  • The side effects associated with taking Zanaflex are typically moderate. Zanaflex has some common side effects. They may include:

    • Runny nose

    • A sore throat

    • Vomiting

    • Constipation

    • Nervous feelings

    • Dry mouth

    • Drowsiness

    • Weakness

    • Flu-like symptoms

    • Blurred vision

    • Uncontrolled muscle movements

    Some people have also experienced urination problems when they use this medication. It is also possible to have abnormal liver function tests while on Zanaflex. Following your regular dosing schedule can help to reduce the risk of these side effects.

    Other side effects, which are less common but might be more severe, could include:

    • Shallow or weak breathing

    • Burning sensation during urination

    • Confusion

    • Hallucinations

    • Lightheadedness

    • Jaundice symptoms

    If there is a yellowing of the skin or eyes, tell your doctor immediately. This may be a sign of jaundice. It is also important to monitor elderly patients for these side effects.

    An allergic reaction can also sometimes occur. Allergic reactions may include hives and trouble breathing. You may also notice swelling in your tongue, throat, lips, and other parts of your face.

    You should call your doctor if you notice any of these side effects or develop any other new or concerning symptoms. This medication is not advised to be used in children due to the potential side effects that may occur.

    The medication may also interfere with another medical condition. Tell your doctor if you have problems like kidney disease to ensure they take note of these potential interactions.

How to take Zanaflex

Your pharmacist will provide you with instructions on how to take your Zanaflex prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Zanaflex can come in different forms and doses, so be sure to follow the specific instructions on your prescription. It is typically prescribed up to three times every day. Some specific instructions may include timing between doses and whether or not to take the medicine with food. You can ask your doctor for medical advice about side effects that may occur, especially with high doses of the medication. Since this is a controlled drug, your doctor may also restrict the maximum dose you can take every day.

What to avoid while taking Zanaflex

Zanaflex has a large number of drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs.

In addition to medical advice about side effects, you should also tell your doctor about other medicines that you use. This includes other CNS depressants. You may need medical help if serious drug interactions occur between Zanaflex and other CNS depressants.

It is generally not advised to continue breastfeeding when you take this medication. Your healthcare professional may weigh the pros and cons, or consider other drugs that could help manage your pain symptoms. Pregnant women might also be advised to consider other drugs.

Do note take Zanaflex with the following medicines:

If you use other drugs that help to control your heart rhythm, report this to the healthcare professional. You should also tell your doctor if you have kidney disease, muscle tone problems, or a renal impairment history.

Since Zanaflex can cause dizziness and weakness, you should not combine it with sleeping pills. Ensure you are not allergic to the drug's active and inactive ingredients before taking it. Refer to the drug information to learn more about the ingredients apart from the tizanidine HCL.

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Zanaflex.

Medication alternatives to Zanaflex

If your healthcare provider prefers to put you on another treatment, they may suggest a muscle relaxant in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Chronic Muscle Pain

    There are cases where patients show signs of chronic pain in their muscles. This can sometimes be related to a chronic condition that the patient has. The doctor may consider other medicines to assist in treating chronic muscle pain. This will generally include medicine that is safer for long-term treatment. You may start with standard dosage forms at the recommended starting dose. The healthcare professional can then gradually increase the dose to suit your needs better.

Zanaflex prescription FAQs

  • How much does Zanaflex cost?

    Your dose and the pharmacy you use to pick up your prescription are the main things that will affect the price.

  • How can I refill my Zanaflex prescription?

    With Zanaflex, you usually get a short-term treatment solution. The doctor will likely send the prescription to a pharmacy of your choice, which allows you to pick up the pills at the local facility.

  • What should you not take Zanaflex with?

    Do not take other drugs that also use ingredients that suppress central nervous system activities. You should also avoid certain antibiotics and heart medications while using this medication.

  • Does Zanaflex relax muscles?

    Zanaflex is a type of muscle relaxant that blocks the transmission of impulses between nerves from the body and the brain. This helps to reduce tension and stiffness in muscles.

  • When is the best time to take Zanaflex?

    Some people prefer to take medicine at the same time every day. This includes morning, afternoon, and evening doses. Tell your doctor if you prefer to use it on an as-needed basis, but this is usually not preferred.

  • How much Zanaflex can you take at once?

    It is generally advised not to take more than 36mg of Zanaflex in a 24-hour period. This is generally divided into three doses during the day. You may start off with a much lower dose, such as a 2 mg or 4 mg dose.

  • Who should not take Zanaflex?

    Do not take Zanaflex if you have liver disease or kidney problems. You should also not use this medication if you are pregnant or breastfeeding. Ask your doctor for medical advice if you currently use herbal products. Some herbal products may cause interactions or an increased risk of certain adverse effects.

  • What happens if I miss a dose of Zanaflex?

    A missed dose may cause a recurrence of your symptoms. Take the missed dose if there is still at least six hours before your next dose. If you are within a six hour window of the next dose, then do not take the missed dose. Alternatively, you can take the missed dose and start with a new schedule. If you take the doses close to each other, you have an increased risk of serious side effects.

  • What happens if I take too much Zanaflex?

    If an overdose occurs, call a poison control center. An overdose of Zanaflex can cause a significant increase in the risk of serious side-effects and even be fatal in some cases. It also raises the risk of causing liver disease as a complication.

3 simple steps to request your Zanaflex prescription today 

Step 1

Book a Zanaflex prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Zanaflex prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Zanaflex prescription.

We can send prescriptions to any local pharmacy.

Zanaflex prescription pricing details

How pricing works

To get a new or refill on your Zanaflex prescription, join our monthly membership and get discounted visits.

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Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
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Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


PlushCare is dedicated to providing you with accurate and trustworthy health information.

  • "Zanaflex (tizanidine): Uses, Dosage, Side Effects, Interactions, Warning." Accessed Oct 5, 2023,

  • Verywell Health. "Zanaflex (Tizanidine Oral)." Accessed Oct 5, 2023,

PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.