Truvada (emtricitabine/tenofovir) prescription available online 

If you are suffering from hepatitis B or human immunodeficiency virus (HIV), Truvada can help. Get a new prescription or refill of Truvada from a board-certified doctor online.*

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Used to treat HIV and hepatitis B

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Truvada (emtricitabine/tenofovir)

Truvada is considered a nucleoside reverse transcriptase inhibitor (NRTI), which functions by treating viral infections. Like many NRTIs, this medication can only be used for HIV and hepatitis B virus treatment. It is ineffective against other sexually transmitted infections because it will not prevent or treat other infections, such as chlamydia, gonorrhea, or syphilis.

Some conditions that Truvada is known to treat include HIV-1 infection and hepatitis B. Truvada is available only by prescription. It is available as a brand-name formulation and not in a generic form. These HIV medicines feature two active drug ingredients. These are tenofovir disoproxil fumarate and emtricitabine. 

Truvada may be prescribed as a film-coated, capsule-shaped tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed Truvada, complete the entire course of the NRTIs unless your doctor specifically tells you to stop.

If you don’t complete your prescription, the NRTIs may not fully treat your HIV or hepatitis B. HIV prevention can also be unsuccessful if you stop using the medicine.

Truvada uses

There are two FDA-approved uses for Truvada, but it may also be used off-label to treat other conditions. This medication can treat HIV and hepatitis B infections. Your online medical professional may not prescribe it for anything other than controlling an HIV infection or hepatitis B infection. It’s also possible that your health care provider may prescribe it for HIV prevention in people susceptible to this type of infection. This is an off-label use.

When you are taking the drug to prevent HIV infection, your healthcare provider can refer to this kind of use as “PrEP” or “pre-exposure prophylaxis.” PrEP can decrease the risk of sexually transmitted HIV by up to 99%.

If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Treating HIV

    Truvada combines the anti-HIV drugs emtricitabine and tenofovir in a single pill. The product can treat people already infected with the HIV virus. It is always used alongside other HIV-1 medicines. For a patient to use Truvada, they need to weigh at least 35 kg (77 lbs).

    Truvada blocks crucial pathways that the virus uses to set up an infection. The presence of this medication in the bloodstream could hinder the spread of HIV in the body or stop the HIV virus from establishing itself.

    To prevent HIV infection, a healthcare provider can suggest off-label use. The medicine can reduce the risk of getting HIV when used with safe sex practices, such as proper and regular condom use, regular risk reduction counseling, and HIV testing.

  • Hepatitis B treatment

    Hepatitis B is a preventable liver infection triggered by the hepatitis B virus (HBV). The virus injures and attacks the liver, making it difficult for the organ to function. Truvada is a combination of different medicines that have some level of activity against hepatitis B.

Truvada side effects

  • The side effects associated with taking Truvada are typically moderate. Most Truvada side effects are associated with weight loss, rashes, and gastrointestinal discomfort. Truvada has some common side effects. They may include:

    • Headaches

    • Loss of appetite

    • Vomiting

    • Upset stomach

    • Depression

    • Trouble sleeping

    • Rash

    • Diarrhea

    • Stomach pain

    Other side effects, which are less common but might be more severe, could include:

    • Unusual muscle aches

    • Abnormal or fast heartbeat

    • Lightheadedness

    • Dizziness

    • Weakness

    • Allergic reactions

    • Liver problems

    • Kidney problems

    • Bone pain

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. If you experience adverse effects from the oral tablet, which can cause an allergic reaction, talk to a health care provider. Classic symptoms of an allergic reaction include flushing, itching, rash, and swelling.

    Most mild side effects with Truvada subside on their own. But other side effects could be long-term, such as the side effects that lead to bone loss, and kidney or liver problems. Although these are serious side effects, they are very rare.

    On another note, Truvada could cause a specific type of diabetes. Clinical trials of Truvada didn’t report side effects such as causing type 1 or type 2 diabetes. But, some patients developed a condition known as nephrogenic diabetes insipidus (NDI) while using this medicine. With NDI, the kidneys don’t work properly. This can cause headaches, dizziness, weight loss very low blood pressure, and more.

    Use of Truvada in young children under age 12 is not advised because the efficacy and safety of the medication has not been established.

How to take Truvada

Your pharmacist will provide you with instructions on how to take your Truvada prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Truvada can come in different forms and doses, so be sure to follow the specific instructions on your prescription. It is typically prescribed as one 200 mg/300 mg tablet a day, preferably with food. Some specific instructions may include using the tablet alongside other antiviral medications for treating HIV.

The dosing can vary based on a person’s body weight. To treat pediatric patients for HIV-1 infection, patients with 17 to less than 22 kg body weight often take one 100 mg /150 mg tablet dose daily. Those weighing 22 to less than 28 kg can have a 133 mg /200 mg tablet dose daily.

As a part of PrEP, for HIV-uninfected patients at risk of getting HIV, it is important to use antiretroviral medication every day. This way, patients can decrease the odds of becoming infected with HIV. The dosage for HIV prevention (PrEP) for adults who weigh 35 kg or over is one 200 mg emtricitabine tablet or 300 mg tenofovir disoproxil fumarate tablet once a day.

What to avoid while taking Truvada

Truvada has 212 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

It is important to avoid any drugs or medication that interfere with Truvada. Some of these drugs can reduce the efficiency of HIV medication, while others can trigger additional side effects.

Using Truvada with didanosine amplifies the didanosine levels in the system. This can cause symptoms of didanosine toxicity such as neuropathy or pancreatitis. When used alongside HIV-1 protease inhibitors, Truvada might lead to tenofovir toxicity. Therefore, patients need careful monitoring. Hepatitis C Antiviral Agents can raise the concentration of tenofovir and could increase the risk of side effects.  

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Truvada.

Truvada can cause mild side effects. However, when mixing it with alcohol, the side effects can be amplified. The packaging on each Truvada product states that Truvada could cause dizziness. This effect can be worse if you take it with some medicines or alcohol. Overall, mixing Truvada with alcohol is not seen as a drastic toxicity concern. But, it is important that you take the necessary precautions and avoid using it with alcohol.

Medication alternatives to Truvada

Other Truvada alternatives are Stribild and Descovy, which are also NRTIs. If your healthcare provider prefers to put you on another treatment, they may suggest another NRTI or a Protease Inhibitor (PI) in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • HIV/AIDS and hepatitis C

    • Atazanavir belongs to a class of medications known as protease inhibitors (PIs). It decreases the amount of HIV in the bloodstream. Even though it can’t cure HIV, when used alongside other medications, it can help treat HIV. This drug can cause side effects such as stomach pain, diarrhea, headaches, etc.

  • HIV virus

    • Enfuvirtide belongs to a class of drugs known as fusion inhibitors. These medications block HIV from entering the CD4 cells of the immune system. These drugs bind to the envelope protein on the virus, preventing it from going through structural changes, which are essential for the virus to fuse. Patients need to administer the product subcutaneously to get the desired result. The possible side effects of this medication are pneumonia, nausea, fatigue, depression, and more.

  • HIV infection

    • Maraviroc (brand name: Selzentry) belongs to a class of drugs called the CCR5 Antagonists. It is an FDA-approved prescription medicine for treating HIV. It can only be recommended in patients whose strain of HIV uses the CCR5 coreceptor. It can’t be used on patients whose infection uses other coreceptors. Possible side effects include stinging, body aches, ear congestion, tenderness around the eyes, dizziness, and more.

  • Increasing effectiveness of HIV medicines

    • Cobicistat belongs to a class of medications known as pharmacokinetic enhancers. These products are a practical choice when the patient must increase the effectiveness of HIV medicine. The goal is to increase systemic exposure to make HIV medicine more effective. Common side effects might include rash, jaundice, nausea, and kidney or liver problems.

Truvada prescription FAQs

  • How much does Truvada cost?

    The average Truvada cost is about $1,871, but the price per unit can vary from $59.14 to $64.98. It comes in 200 mg-300 mg dosages and is more affordable than Stribild and Descovy. With coupons and discounts, you can reduce some of the costs.

  • How can I refill my Truvada prescription?

    You can only get a refill of Truvada via prescription from a doctor. Book a virtual appointment with one of our top-rated, board-certified doctors. After a qualifying evaluation, our doctor can send the refill to your local pharmacy.

  • Who should not take Truvada?

    Talk to a healthcare provider if you have liver or kidney disease or plan to conceive or breastfeeding. Don’t take HIV medicines if allergic to ingredients unless your healthcare provider instructs you otherwise.

  • Can you drink alcohol while taking Truvada?

    If you use Truvada, the HIV treatment can cause dizziness. This effect can worsen if you take the drug with other medicines or alcohol. Use this product cautiously, and talk to a doctor if you have a drinking problem.

  • Should I take Truvada in the morning or at night?

    It’s best to take a pill at night before bed. If you are taking it to prevent HIV, you should use it before sexual exposure to HIV. Talk to a healthcare provider to find the best time to use this medication.

  • What happens if I miss a dose of Truvada?

    Take the missed dose as soon as you remember it. However, if it is about time for the next dose, skip the missed dose, and stick to your regular daily schedule. Avoid taking double doses.

  • What happens if I take too much Truvada?

    Call a doctor immediately if you think you have taken too much Truvada. Because of its impact on the kidneys, this HIV medicine could trigger serious kidney damage. This is why it is important to stick to the recommended guidelines and avoid a Truvada overdose.

3 simple steps to request your Truvada prescription today

Step 1: Book an appointment

Step 1

Book a visit with a doctor to discuss Truvada.

During your first visit, your PlushCare doctor will review your medical history and health goals.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your physician regarding Truvada medication.

Visit with a doctor on your smartphone or computer. Lab work is required, and they’ll send an order to your preferred lab or deliver a lab kit to your home. Once your results are available, your doctor will review them and discuss all treatment options.

Step 3: pick up at local pharmacy

Step 3

Pick up your Truvada medication, if prescribed.

Prescriptions are provided based on eligibility and safety.  Our physicians will prescribe medications and monitor body functions to ensure safety while taking Truvada.

Truvada prescription pricing details

How pricing works

To get a new or refill on your Truvada prescription, join our monthly membership and get discounted visits.

Paying with insurance



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30 days of free membership

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  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.