Rexulti (Brexpiprazole) prescription available online

If you suffer from schizophrenia or major depressive disorder, Rexulti can help. Get a new prescription or refill of Rexulti today from a board-certified doctor online.*

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Used to treat schizophrenia and major depressive disorder

Available as a tablet

Convenient online Rexulti prescriptions

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Rexulti (Brexpiprazole)

Rexulti is considered an atypical antipsychotic or second-generation antipsychotic, which functions by changing the actions of chemicals in the brain. This prescription medicine adjusts the balance of neurotransmitters such as serotonin and dopamine. An imbalance of neurotransmitters is associated with mental health conditions such as schizophrenia and depression.

Like any antipsychotic drug, Rexulti can only be used for schizophrenia and, sometimes, major depressive disorder. Rexulti is ineffective against psychosis related to dementia (memory loss) because it will increase the risk of death.

Some conditions that Rexulti is known to treat include schizophrenia and, as an adjunctive treatment, major depressive disorder (MDD). Rexulti is available only by prescription. It is available in a generic formulation under different brand names, including Rxulti.

Rexulti may be prescribed as a tablet that you swallow. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed Rexulti, be sure to complete the entire course of the atypical antipsychotic unless your doctor specifically tells you to stop.

If you don’t complete your prescription, the atypical antipsychotic may not fully treat your schizophrenia or major depressive disorder. 

Rexulti uses

There are two FDA-approved uses for Rexulti, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe Rexulti for the following reasons. It’s also possible that your healthcare provider may prescribe Rexulti for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Schizophrenia treatment

    Rexulti rebalances neurotransmitters dopamine and serotonin to improve behavior, thinking, and mood.

    People with schizophrenia experience symptoms such as hallucinations, delusions, lack of motivation, trouble speaking, loss of interest, and disorganized thinking.

    Rexulti can help with some of the symptoms of schizophrenia. After all, serotonin is implicated in several behaviors and bodily functions impaired in schizophrenia. These include cognition, memory, perception, attention, mood, aggression, appetite, sex drive, and energy levels.

    At the same time, an impaired balance of dopamine can also contribute to the development and progression of schizophrenia.

  • Major depressive disorder (MDD) adjunct treatment

    Rexulti has FDA approval for use as an adjunctive treatment for depression. In other words, doctors don’t prescribe Rexulti as the only medication or treatment for major depressive disorder. Instead, Rexulti is only used in combination with antidepressant therapy.

    The use of Rexulti can reduce the severity of depression symptoms. This antipsychotic medication works because serotonin and dopamine, i.e. their imbalances, are also involved in depression.

Rexulti side effects

  • The side effects associated with taking Rexulti are typically mild to severe. Most Rexulti side effects are associated with restlessness. Rexulti has some common side effects. They may include:

    • Akathisia (feeling of restlessness and inability to sit still)

    • Headache

    • Weight gain

    Other side effects, which are less common but might be more severe, could include:

    • Insomnia

    • Tiredness

    • Tremors

    • Nasopharyngitis (common cold)

    • Stroke

    • Problems regulating body temperature

    • Seizures

    • Allergic reaction

    • Increased blood cholesterol and/or triglyceride levels

    • High blood sugar levels

    • Trouble swallowing due to neck spasms

    • Orthostatic hypotension (abrupt decrease in blood pressure when changing positions)

    • Neuroleptic malignant syndrome (potentially fatal symptom complex) indicated by a fast heart rate, confusion, fever, hypertension or hypotension, sweating, and rigid muscles

    • Tardive dyskinesia (unintentional muscle movements) characterized by excessive blinking, unintentionally waving your arms, trouble controlling face/tongue movements

    • Risk of suicidal thoughts

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms.

    Use of Rexulti in young children under age 12 is not advised because it it is not known whether it is safe or effective for this age group. This medication is formulated for adult patients mainly.

How to take Rexulti

Your pharmacist will provide you with instructions on how to take your Rexulti prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Rexulti can come in different forms and doses, so follow the specific instructions on your prescription throughout the treatment period. This antipsychotic medication is typically prescribed at a low dose of 1mg daily on days 1 through 4 as the initial dose for schizophrenia treatment.

The titration regimen is based on response and tolerability and may include 2mg daily on days 5 through 7, then 4mg once daily on day 8. The maintenance dose or usual dose is 2mg to 4mg once a day. The maximum daily dose of Rexulti is 4mg.

Regarding Rexulti as an adjunctive treatment for depression, the initial dose is 0.5mg to 1mg once a day. The titration regimen is around 1mg once a day to 2mg once a day. A usual dose of Rexulti is 2mg once a day. The maximum daily dose is 3mg.

Some specific instructions may include taking Rexulti at the same time every day to make it a habit and avoid missing a dose, but it is optional.

What to avoid while taking Rexulti

Rexulti has 534 drug interactions. Some drug interactions include medications for mood disorders, antifungal medications, antibiotics, antiviral medications, and anticonvulsants.

Don’t change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter medicines.

It is essential to follow the instructions provided by a doctor when taking Rexulti. Avoid cutting the tablet in half, crushing, or chewing it. You need to swallow the whole Rexulti pill.

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Rexulti.

Some research shows that regular alcohol consumption may decrease the benefits of Rexulti and increase the risk of side effects. Alcohol may also reduce Rexulti’s ability to do its job, making it harder to manage schizophrenia or depression.

Avoid driving or engaging in hazardous activity until you know how Rexulti will affect you. Rexulti, like other atypical antipsychotics, could impair your reactions and put you at a higher risk of accidents.

Additionally, avoid getting up too quickly from a sitting or lying position so you don’t get dizzy when taking Rexulti.

In hot weather, avoid becoming dehydrated or overheating. Rexulti makes regulating body temperature more complex so that you could be at a higher risk of dehydration and its consequences.

Medication alternatives to Rexulti

If your healthcare provider prefers to put you on another treatment, they may suggest another atypical antipsychotic or an antipsychotic in another drug class. Here are some common doctor-recommended Rexulti alternatives based on your health issue:

  • Schizophrenia

    Geodon (ziprasidone)

    Zyprexa (Olanzapine)

    Latuda (lurasidone)

    Quetiapine (Seroquel)

    Risperidone (Risperdal)

    Abilify (Aripiprazole)

    Saphris (asenapine)

    Clozaril, Versacloz (clozapine)

  • Major depressive disorder

    Abilify (Aripiprazole)

    Zyprexa (Olanzapine)

    Quetiapine (Seroquel)

    Risperidone (Risperdal)

Rexulti prescription FAQs

  • How much does Rexulti cost?

    The cost of Rexulti depends on the pharmacy you visit. In some pharmacies, the price of Rexulti is around $1,413 per 30 tablets, whereas in others, it’s around $1300 or goes over $1600. Rexulti is a relatively new medication, and generic options aren’t available. This could explain why Rexulti is on the pricier side. People with insurance usually pay less due to the copay option. Also, there are programs that you can sign up for at a discounted price.

  • How can I refill my Rexulti prescription?

    You can refill Rexulti prescription the same way as with other medications. Call a healthcare provider to get a prescription refill, and they will send the request if they think it is necessary based on your medical history.

    Another option is to request a Rexulti refill in a pharmacy, but keep in mind they are obligated to contact your healthcare provider before going through with the request. A quick and simple strategy to refill Rexulti prescription is to see a doctor online using the PlushCare platform.

    The healthcare professionals and customer service team process refill quickly, and you just need to pick them up.

  • What are the unusual urges with Rexulti?

    Unusual urges associated with Rexulti include binge eating, compulsive eating, gambling, sexual urges, compulsive shopping, and other compulsive behaviors. Patients who experience compulsive behaviors should consult their doctor immediately. Friends or family who notice signs of these behaviors in people taking Rexulti should encourage them to talk to their healthcare provider.

  • Does Rexulti make you emotional?

    It is possible to become more emotional when taking Rexulti. This antipsychotic medication can increase anger or induce other mood or emotion-related changes. Also, Rexulti is linked to an increased risk of suicidal thoughts and behaviors, particularly in young adults i.e. people younger than 24 years.

  • Who should not take Rexulti?

    Older adults (65 years or older) with dementia-related psychosis shouldn’t take Rexulti. Elderly patients with dementia-related psychosis are at an increased risk of death when taking Rexulti.

    Don’t take Rexulti if you are allergic to brexpiprazole. Before getting a prescription for Rexulti, inform your doctor if you have (or have a history of) diabetes or high blood sugar, kidney disease, liver disease, high cholesterol and triglycerides, high or low blood pressure, heart problems, heart attack, stroke, seizure, and low white blood cell counts. Mention other drugs you're taking to avoid the risk of drug interactions.

    Women who are pregnant or breastfeeding shouldn’t use Rexulti unless their doctor approves.

    Since the medication is for adult patients, children shouldn't use it.

  • Is Rexulti a mood stabilizer?

    Rexulti belongs to a class of medications called atypical antipsychotics. The main function of Rexulti and other drugs of this kind is to restore the balance of some natural substances in the brain. However, Rexulti may improve mood, sleep, appetite, and energy levels. That's why Rexulti is also used as an adjunctive treatment to manage major depressive disorder (MDD).

  • What happens if I miss a dose of Rexulti?

    If you miss a dose of Rexulti take it as soon as you remember. That said if it’s almost time for the next dose, skip the missed dose and take the regular one. Avoid taking two doses of Rexulti at once to compensate for the missed dose. The risk of side effects would increase. Set up a reminder to take Rexulti on time. That way, you won’t miss a dose.

  • What happens if I take too much Rexulti?

    If you take too much Rexulti, call a healthcare provider or the local Poison Control Center. Make sure to seek emergency medical attention immediately. Taking too much Rexulti could lead to serious adverse reactions.

3 simple steps to request your Rexulti prescription today 

Step 1: Book an appointment

Step 1

Book a Rexulti prescription request appointment.

You can book a same-day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Rexulti prescription.

Visit a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Rexulti prescription.

We can send prescriptions to any local pharmacy.

Rexulti prescription pricing details

How pricing works

To get a new or refill on your Rexulti prescription, join our monthly membership and get discounted visits.

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Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
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Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.