Mental Health

Rexulti (Brexpiprazole) prescription available online

If you suffer from schizophrenia or major depressive disorder, Rexulti can help. Get a new prescription or refill of Rexulti today from a board-certified primary care doctor online.*

Used to treat schizophrenia and major depressive disorder Available as a tablet Convenient online Rexulti prescriptions

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*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card. PlushCare doctors cannot treat all cases of major depression or schizophrenia. Our primary care physicians can conduct an initial evaluation of your symptoms but may need to refer you to a specialist or for in-person treatment. If you are experiencing life-threatening symptoms, seek emergency medical attention immediately.

About Rexulti (Brexpiprazole)

Rexulti is considered an atypical antipsychotic or second-generation antipsychotic, which functions by changing the actions of chemicals in the brain. This prescription medicine adjusts the balance of neurotransmitters such as serotonin and dopamine. An imbalance of neurotransmitters is associated with mental health conditions such as schizophrenia and depression.

Like any antipsychotic drug, Rexulti can only be used for schizophrenia and, sometimes, major depressive disorder. Rexulti is ineffective against psychosis related to dementia (memory loss) because it will increase the risk of death.

Some conditions that Rexulti is known to treat include schizophrenia and, as an adjunctive treatment, major depressive disorder (MDD). Rexulti is available only by prescription. It is not yet available as a generic medication.

Rexulti may be prescribed as a tablet that you swallow. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed Rexulti, be sure to take the atypical antipsychotic as prescribed unless your doctor specifically tells you to stop.

If you don’t adhere to your prescription, the atypical antipsychotic may not adequately treat your schizophrenia or major depressive disorder.

Rexulti uses

There are two FDA-approved uses for Rexulti, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe Rexulti for the following reasons. It’s also possible that your healthcare provider may prescribe Rexulti for other reasons not listed here. Ask your online doctor if you have questions about why a medication is prescribed.

Schizophrenia treatment

Rexulti rebalances neurotransmitters dopamine and serotonin to improve behavior, thinking, and mood.

People with schizophrenia experience symptoms such as hallucinations, delusions, lack of motivation, trouble speaking, loss of interest, and disorganized thinking.

Rexulti can help with some of the symptoms of schizophrenia. After all, serotonin is implicated in several behaviors and bodily functions impaired in schizophrenia. These include cognition, memory, perception, attention, mood, aggression, appetite, sex drive, and energy levels.

At the same time, an impaired balance of dopamine can also contribute to the development and progression of schizophrenia.

Major depressive disorder (MDD) adjunct treatment

Rexulti has FDA approval for use as an adjunctive treatment for depression. In other words, doctors don’t prescribe Rexulti as the only medication or treatment for major depressive disorder. Instead, Rexulti is only used in combination with antidepressant therapy.

The use of Rexulti can reduce the severity of depression symptoms. This antipsychotic medication works because serotonin and dopamine, i.e. their imbalances, are also involved in depression.

Rexulti side effects

The side effects associated with taking Rexulti are typically mild. Common side effects of Rexulti may include:

Insomnia
Tiredness
Headache
Weight gain

Other side effects, which are less common but might be more severe, could include:

Akathisia (feeling of restlessness and inability to sit still)
Tremors
Nasopharyngitis (common cold)
Stroke
Problems regulating body temperature
Seizures
Allergic reaction
Increased blood cholesterol and/or triglyceride levels
High blood sugar levels
Trouble swallowing due to neck spasms
Orthostatic hypotension (abrupt decrease in blood pressure when changing positions)
Neuroleptic malignant syndrome (potentially fatal symptom complex) indicated by a fast heart rate, confusion, fever, hypertension or hypotension, sweating, and rigid muscles
Tardive dyskinesia (unintentional muscle movements) characterized by excessive blinking, unintentionally waving your arms, trouble controlling face/tongue movements
Risk of suicidal thoughts

You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms.

Use of Rexulti in young children under age 12 is not advised because it it is not known whether it is safe or effective for this age group. This medication is formulated for adult patients mainly.

How to take Rexulti

Your pharmacist will provide you with instructions on how to take your Rexulti prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Rexulti can come in different forms and doses, so follow the specific instructions on your prescription throughout the treatment period. This antipsychotic medication is typically prescribed at a low dose of 1mg daily on days 1 through 4 as the initial dose for schizophrenia treatment.

The titration regimen is based on response and tolerability and may include 2mg daily on days 5 through 7, then 4mg once daily on day 8. The maintenance dose or usual dose is 2mg to 4mg once a day. The maximum daily dose of Rexulti is 4mg.

Regarding Rexulti as an adjunctive treatment for depression, the initial dose is 0.5mg to 1mg once a day. The titration regimen is around 1mg once a day to 2mg once a day. A usual dose of Rexulti is 2mg once a day. The maximum daily dose is 3mg.

Some specific instructions may include taking Rexulti at the same time every day to make it a habit and avoid missing a dose, but it is optional.

What to avoid while taking Rexulti

Rexulti has many possible drug interactions. Some drug interactions include medications for mood disorders, antifungal medications, antibiotics, antiviral medications, and anticonvulsants.

Don’t change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter medicines.

It is essential to follow the instructions provided by a doctor when taking Rexulti. Avoid cutting the tablet in half, crushing, or chewing it. You need to swallow the whole Rexulti pill.

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Rexulti.

Some research shows that regular alcohol consumption may decrease the benefits of Rexulti and increase the risk of side effects. Alcohol may also reduce Rexulti’s ability to do its job, making it harder to manage schizophrenia or depression.

Avoid driving or engaging in hazardous activity until you know how Rexulti will affect you. Rexulti, like other atypical antipsychotics, could impair your reactions and put you at a higher risk of accidents.

Additionally, avoid getting up too quickly from a sitting or lying position so you don’t get dizzy when taking Rexulti.

In hot weather, avoid becoming dehydrated or overheating. Rexulti makes regulating body temperature more complex so that you could be at a higher risk of dehydration and its consequences.

Medication alternatives to Rexulti

If your healthcare provider prefers to put you on another treatment, they may suggest another atypical antipsychotic or an antipsychotic in another drug class. Here are some common doctor-recommended Rexulti alternatives based on your health issue:

Schizophrenia

Geodon (ziprasidone)

Zyprexa (Olanzapine)

Latuda (lurasidone)

Quetiapine (Seroquel)

Risperidone (Risperdal)

Abilify (Aripiprazole)

Saphris (asenapine)

Clozaril, Versacloz (clozapine)

Major depressive disorder

Abilify (Aripiprazole)

Zyprexa (Olanzapine)

Quetiapine (Seroquel)

Risperidone (Risperdal)

Rexulti prescription FAQs

How much does Rexulti cost?

The cost of Rexulti depends on the pharmacy you visit. In some pharmacies, the price of brand-name Rexulti is as much as $1,413 per 30 tablets, whereas in others, it’s around $1300 or goes over $1600. Rexulti is a relatively new medication, and generic options aren’t yet available. This could explain why Rexulti is on the pricier side. People with insurance usually pay significantly less due to the copay. Also, there are programs that you can sign up for at a discounted price.

How can I refill my Rexulti prescription?

You can refill Rexulti prescription the same way as with other medications. Call a healthcare provider to get a prescription refill, and they will send the request if they think it is necessary based on your medical history.

Another option is to request a Rexulti refill in a pharmacy, but keep in mind they are obligated to contact your healthcare provider before going through with the request. A quick and simple strategy to refill Rexulti prescription is to see a doctor online using the PlushCare platform.

The healthcare professionals and customer service team process refill quickly, and you just need to pick them up.

What are the unusual urges with Rexulti?

Although quite rare, unusual urges associated with Rexulti include binge eating, compulsive eating, gambling, sexual urges, compulsive shopping, and other compulsive behaviors. Patients who experience compulsive behaviors should consult their doctor immediately. Friends or family who notice signs of these behaviors in people taking Rexulti should encourage them to talk to their healthcare provider.

Does Rexulti make you emotional?

It is possible to become more emotional when taking Rexulti. This antipsychotic medication can increase anger or induce other mood or emotion-related changes. Also, Rexulti is linked to an increased risk of suicidal thoughts and behaviors, particularly in young adults i.e. people younger than 24 years.

Who should not take Rexulti?

Older adults (65 years or older) with dementia-related psychosis shouldn’t take Rexulti. Elderly patients with dementia-related psychosis are at an increased risk of death when taking Rexulti.

Don’t take Rexulti if you are allergic to brexpiprazole. Before getting a prescription for Rexulti, inform your doctor if you have (or have a history of) diabetes or high blood sugar, kidney disease, liver disease, high cholesterol and triglycerides, high or low blood pressure, heart problems, heart attack, stroke, seizure, and low white blood cell counts. Mention other drugs you're taking to avoid the risk of drug interactions.

Women who are pregnant or breastfeeding shouldn’t use Rexulti unless their doctor approves.

Since the medication is for adult patients, children shouldn't use it.

Is Rexulti a mood stabilizer?

Rexulti belongs to a class of medications called atypical antipsychotics. The main function of Rexulti and other drugs of this kind is to restore the balance of some natural substances in the brain. However, Rexulti may improve mood, sleep, appetite, and energy levels. That's why Rexulti is also used as an adjunctive treatment to manage major depressive disorder (MDD).

What happens if I miss a dose of Rexulti?

If you miss a dose of Rexulti take it as soon as you remember. That said if it’s almost time for the next dose, skip the missed dose and take the regular one. Avoid taking two doses of Rexulti at once to compensate for the missed dose. The risk of side effects would increase. Set up a reminder to take Rexulti on time. That way, you won’t miss a dose.

What happens if I take too much Rexulti?

If you take too much Rexulti, call a healthcare provider or the local Poison Control Center. Make sure to seek emergency medical attention immediately. Taking too much Rexulti could lead to serious adverse reactions.

Step 1

Book a Rexulti prescription request appointment.

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Step 2

Talk to your medical provider regarding your Rexulti prescription.

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Step 3

Pick up your Rexulti prescription, if provided.

We can send prescriptions to any local pharmacy.

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