Lioresal (baclofen) prescription available online

If you are suffering from muscle spasms, Lioresal (baclofen) can help. Get a new prescription or refill of baclofen from a board-certified doctor online.*

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FDA-approved for muscle spasms and pain

Alleviate symptoms of multiple sclerosis and spinal cord injuries

Manage muscle pain and weakness

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Lioresal (baclofen)

Baclofen is considered a skeletal muscle relaxant, which functions by relaxing the muscles. Like other muscle relaxer medications, baclofen tablets are used to reduce and relieve excessive tension in the muscles. 
Baclofen is used to treat muscle spasms caused by multiple sclerosis (MS), spinal cord injury, and other spinal cord diseases. Baclofen is available only by prescription. It is available in a generic formulation as well as under different brand names, including Lioresal. 
Baclofen may be prescribed as a tablet. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed. 
If you are prescribed baclofen, be sure to follow the directions that were provided by your health care professional on how to take your muscle relaxant.

Baclofen uses

There are several FDA-approved uses for baclofen, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your health care provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Muscle spasms

    Baclofen is FDA-approved to help treat the pain from muscle spasms resulting from multiple sclerosis (MS), cerebral palsy, spinal cord injuries, and other spinal diseases. Baclofen may also help relieve muscle pain. It is important to note that it does not cure these conditions but it may allow other treatments, such as physical therapy, to be more helpful in improving your condition

Baclofen side effects

  • The side effects associated with taking baclofen are typically mild. Most baclofen side effects are associated with drowsiness. Baclofen has some common side effects. They may include: 

    • Feeling dizzy, tired, or weak 

    • Headache 

    • Nausea and/or vomiting 

    • Confusion 

    • Constipation 

    • Low blood pressure 

    Other side effects, which are less common but might be more severe, could include: 

    • Muscle pain or muscle weakness 

    • Severe dizziness 

    • Problems with urinary retention 

    Ask your doctor for medical advice you notice any adverse effects, or if you develop any other new or concerning symptoms. Baclofen can be taken in tablet or liquid form by children over the age of one month old. The use of baclofen in pediatric populations is usually managed by a specialist. At this time, PlushCare does not have specialists that manage these pediatric conditions. 

How to take Baclofen

Your pharmacist will provide you with instructions on how to take your baclofen prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Baclofen can come in different forms and doses, so be sure to follow the specific instructions on your prescription. Baclofen dosage can range from 5 mg to 20 mg, taken between once and three times daily. It is important to note that for patients with long term baclofen use, it should not be stopped abruptly as it can lead to withdrawal symptoms. Please follow your doctor’s instructions when discontinuing this medication. 

What to avoid while taking Baclofen

Baclofen has many drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Possible drug interactions with baclofen include:

  • Adderall (amphetamine/dextroamphetamine)

  • Neurontin (gabapentin)

  • Vitamin D3 (cholecalciferol)

  • Lyrica (pregabalin)

  • Lasix (furosemide)

  • Opiates

Ask your doctor about drinking alcohol while taking baclofen. It is generally not advisable to consume alcohol during treatment with baclofen. Alcohol can increase nervous system side effects, such as dizziness, drowsiness, and difficulty concentrating. Drinking alcohol with baclofen can also cause decreased alertness and impaired judgment. 

Medication alternatives to baclofen

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another muscle relaxant or spasticity medication in another drug class. Here are some common doctor-recommended alternatives based on your health issue: 

Baclofen prescription FAQs

  • How much does baclofen cost?

    Depending on your pharmacy, baclofen tablets cost around $20-$50 for a supply of thirty 10 mg tablets without insurance. Baclofen is a generic brand, and brand-name medications may cost more. Price also varies with insurance coverage. Our prescription discount card helps members save up to 80% on prescriptions.

  • How can I refill my baclofen prescription?

    To refill your baclofen prescription, book a virtual appointment with one of our top rated board-certified doctors. After a qualifying evaluation, your prescription will be sent to your local pharmacy for pickup.

  • Who should not take baclofen?

    Before taking baclofen, tell your doctor if you have:

    • If you're taking CNS depressant medications 

    • Kidney disease 

    • Mental illness, such as schizophrenia 

    • Seizure disorder 

    • Nervous system disorder 

    • If you're pregnant or planning to become pregnant 

    • A history of stroke 

    • Parkinson’s disease 

    • Rheumatologic conditions 

  • What are the major side effects of baclofen?

    The major side effects of baclofen include muscle weakness, mood changes, severe dizziness.

  • How many hours does baclofen last?

    Baclofen has a short half-life, which ranges between two and six hours. That means it takes about 2-6 hours for half of the medication to be removed from the body in an average healthy person.

  • Should I avoid certain foods while taking baclofen?

    Baclofen is not known to interact with food.

  • What happens if I miss a dose of baclofen?

    If you miss a dose of baclofen, take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next dose. Avoid taking two doses to make up for a missed dose.

  • What happens if I take too much baclofen?

    If you've taken too much baclofen, seek emergency medical attention or contact your local poison control center. Overdose symptoms may include muscle weakness, shallow breathing, seizure, or loss of consciousness.

3 simple steps to request your baclofen prescription today 

Step 1

Book a baclofen prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your baclofen prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your baclofen prescription.

We can send prescriptions to any local pharmacy.

Baclofen prescription pricing details

How pricing works

To get a new or refill on your baclofen prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • Cigna

Paying without insurance



First month free



30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.


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PlushCare content is reviewed by MDs, PhDs, NPs, nutritionists, and other healthcare professionals. Learn more about our editorial standards and meet the medical team. The PlushCare site or any linked materials are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.