Rybelsus (semaglutide) prescription available online

Rybelsus (semaglutide) is proven to lower A1C in type 2 diabetes patients. Get a new prescription or refill of Rybelsus today from a board-certified doctor online.

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Rybelsus (semaglutide) is proven to lower A1C in type 2 diabetes patients. Get a new prescription or refill of Rybelsus today from a board-certified doctor online.

Medication services are available for adults and kids (3+)

Top-quality, board-certified doctors

Insurance accepted, but not required

Prescriptions sent to your local pharmacy*

*Prescriptions provided at the doctor’s discretion

We accept these insurance plans and many more!

Most patients with in-network insurance pay $30 or less. Paying without insurance? New patient visits are $129, and follow-ups are only $99 for members.

Don’t see your provider listed? Email [email protected]  or call  (888) 564-4454  to talk to a PlushCare specialist.

3 simple steps to request your Rybelsus prescription today 

Step 1

Book a Rybelsus prescription request appointment. 

Book a same-day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Rybelsus prescription. 

Talk with a doctor on your smartphone or computer.

Step 3

Pick up your Rybelsus prescription. 

We can send prescriptions to any local pharmacy.

Rybelsus prescription pricing details

How pricing works

To get a new or refill on your Rybelsus prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free

First visit


For all visits

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free

First visit


Repeats only $99

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129 and follow-ups are only $99 for active members.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Rybelsus prescription FAQs

  • How much does Rybelsus cost?

    When a healthcare provider prescribes Rybelsus, it is essential to note that there are different strengths that they can decide on. Most patients start with a 3mg dose, then go up to a 7mg dose after one month.

    There are some cases where the patient requires a more potent dose after this adjustment. Each quantity has its associated price. In addition to dosage, you also have to focus on where you get your prescription. Only some pharmacies may offer the medication at the same price. Online prescription services may also differ in terms of cost for Rybelsus. 

  • How can I refill my Rybelsus prescription?

    Rybelsus is a long-term treatment solution that you will consume over an extended period. This means that you will need to get a refill for your prescription regularly. After the first month of use, you may need to revisit your healthcare provider to check on progress. At this time, they give you a prescription for a more potent dose. Another check-up may be required in the next month for further evaluation. After these checkups, you will usually get a repeat prescription to pick up a refill for the Rybelsus once a month. 

  • What happens if you take Rybelsus after eating?

    The ingredients you add to your prepared meals are unlikely to interact with Rybelsus. With this said, taking Rybelsus only a short distance from a meal is generally advised. This is because food may reduce the amount of the active chemicals your body absorbs. In turn, this can adversely affect the efficacy of the drug. Instead, wait at least 30 minutes after you consume Rybelsus before you have a meal. This can help to improve the efficacy that the medication provides. 

  • What time of day should Rybelsus be taken?

    Rybelsus is a pill that you take once per day. In most cases, your healthcare provider will advise you to take the medication when you get up in the morning. This reduces the risk of missing a dose as it becomes part of your daily routine. 

  • How long does it take to get used to Rybelsus?

    You will start with a 3mg dose of Rybelsus. It takes around 30 days for your body to get used to this dose, which is when the doctor begins to prescribe the 7mg dose. By this time, your body should already have gotten used to including Rybelsus in your day-to-day lifestyle. You should notice that the drug improves blood sugar in the first month.

  • Who should not take Rybelsus?

    It is essential to avoid using Rybelsus if you have a history of MTC or MEN 2. Tell your doctor if you have a personal or family history of these conditions. They can assess if the individual or family history may affect you in such a way that you should not use these prescription drugs. You should also carefully assess the ingredients that are used to produce Rybelsus. If you have experienced allergic reactions to any of these ingredients in the past, then it is also best to avoid this medication. 

  • What happens if I miss a dose of Rybelsus?

    If you miss a dose, could you be sure to take it when you remember it? With this said, ensure you do not take Rybelsus too close to a meal, as it can reduce efficacy. You should also only take medicine if it is still on the same day that you had the missed dose. It would be best if you never attempted to take two tablets to make up for the previously missed dose. This might cause low blood sugar.

  • What happens if I take too much Rybelsus?

    If you digest too much of these pills, then the Rybelsus can cause a significant drop in your blood glucose levels. This can lead to severe hypoglycemia (low blood sugar levels), which could cause you to pass out and lose consciousness. 

About Rybelsus (semaglutide) prescription medicine

Rybelsus is considered a glucagon-like peptide-1 (GLP-1) agonist, which functions by performing three specific functions that all contribute to improved blood glucose control. The medication helps increase the amount of insulin the pancreas releases and reduces the sugar the liver releases. The drug also works by slowing down the rate at which food leaves the stomach.  Like any glucagon-like peptide-1 (GLP-1) agonist, this medication can only be used for type 1 diabetes. It is ineffective against type 1 diabetes because it will not be able to increase the amount of insulin that the patient’s pancreas can produce.

Some conditions that Rybelsus is known to treat include type 2 diabetes. Rybelsus is available only by prescription. The medication uses the active ingredient semaglutide. It is important to note that Rybelsus is not available under any generic names or options. It is only possible to find this drug in its brand name. 

Rybelsus may be prescribed as a tablet in most cases. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage you are prescribed.

If you are prescribed Rybelsus, be sure to complete the entire course of the anti-diabetic drug unless your doctor specifically tells you to stop.

If you don’t complete your prescription, the glucagon-like peptide-1 (GLP-1) agonist may not fully treat your type 2 diabetes.  This is generally a long-term treatment solution, and there are precise instructions that you need to follow if you want to see improvements in your diabetes management.

Rybelsus (semaglutide) prescription uses

There is only one FDA-approved use for Rybelsus. It is important to note that Rybelsus is generally not used for off-label purposes due to the specific actions that the drug performs. Your online medical professional may prescribe it for the following reasons. It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. Ask your online doctor or pharmacist if you have questions about why a medication is prescribed.

  • Type 2 Diabetes

    The FDA has provided approval for the use of Rybelsus in patients who have been diagnosed with type 2 diabetes. With this said, Rybelsus is usually not a first-line treatment option for people with this condition. Instead, it is an excellent alternative to other medications generally considered the first line of defense against type 2 diabetes. If the patient uses Metformin with little results, the healthcare provider might consider switching them to Rybelsus. 

    The manufacturer created Rybelsus to address three of the most critical areas that affect blood glucose control in people with type 2 diabetes. First, the medication assists in stimulating the pancreas. This causes the organ to release more insulin in cases where the patient experiences an increase in blood glucose levels. At the same time, the medication also ensures the liver does not release too much sugar, which can impact blood glucose levels. Rybelsus also causes a reduction in the rate at which food moves from the stomach toward the digestive tract. This helps to provide a more gradual release of sugars into the blood circulatory system. 

    Rybelsus is used to help manage blood sugar. Diet and exercise also play an important part when treating diabetes. Patients can use a weight loss coach at PlushCare to help them manage their diet and exercise program.

Rybelsus (semaglutide) prescription side effects

  • The side effects of Rybelsus are typically mild. Most Rybelsus side effects are associated with the digestive tract. Rybelsus has some common side effects. They may include:

    It is common for people to experience nausea and vomiting, as well as diarrhea, when they first start the medication. These side effects of Rybelsus will often reemerge when the patient has a change in the dose they take. 

    Other side effects of Rybelsus, which are less common but might be more severe, can consist of a rapid heartbeat, gallbladder problems, and even a severe allergic reaction. Here we look at the more serious side effects of Rybelsus:

    • Thyroid Problems: There is a rare risk of problems developing with the Thyroid gland. This gland plays a vital role in metabolism and several other bodily functions. Some reports of Thyroid tumors have been noted among individuals who take Rybelsus. The manufacturer has also warned about a risk of cancerous tumors on the Thyroid gland. This could potentially lead to Thyroid cancer. If you develop Thyroid tumors, you may also experience problems with Thyroid C cell function. In the event of Thyroid tumors, it is also possible for the gland to experience alterations in hormone production.

    • Pancreatitis: Individuals also have a risk of experiencing inflammation in their pancreas while they take Rybelsus. This condition may lead to severe pain that occurs in the abdomen. The pain will not go away. Some people may vomit while they experience the pain symptoms.  This can make the pancreas less effective, further affecting blood sugar control. Some people may experience severe pain if these side effects of Rybelsus occur.

    • Hypoglycemia: Due to the reduction in blood glucose and the increase in insulin, some patients may also experience low blood sugar when they use the medication. In this case, the patient is at risk of severe side effects if there is a significant drop in blood sugar levels. Some signs include dizziness, changes in mood, irritability, weakness, and a headache. Severe weakness, a very fast heartbeat, and anxiety can also happen. It is possible to experience vision problems related to low blood sugar too. These vision problems related to hypoglycemia usually present themselves as blurred vision.

    • Kidney Failure: There is also a slight risk of kidney failure when using Rybelsus daily. The risk of kidney failure is much higher among individuals who already have existing problems with their kidneys. These complications may cause dehydration, vomiting, nausea, and diarrhea. 

    • Gallbladder Side-Effects: There are also some rare cases where Rybelsus causes problems with the gallbladder. Upper abdomen pain, stool that has a clay color, a fever, and signs of jaundice can signal the presence of gallbladder issues. 

    • Allergic Reaction: There is also a risk of an allergic reaction when a patient uses Rybelsus. A severe allergic reaction can sometimes be fatal if the patient does not receive treatment promptly. Swelling in the mouth, such as the tongue, lips, and face, are signs of allergic reactions. An allergic reaction can also make breathing difficult, cause a rapid heartbeat, and make the person feel dizzy. Skin rashes are also common when an allergic reaction occurs. Individuals should be aware of allergic reaction symptoms when using these prescription drugs. Severe allergic reactions should be reported to the emergency department.

    You should call your doctor if you notice any of these side effects or develop other new or concerning symptoms. Use of Rybelsus in young children under age 12 is not advised because these cases are generally related to type 1 diabetes. The specific mechanisms that Rybelsus uses to control blood sugar levels do not work in patients with type 1 diabetes. It may cause a severe risk of hypoglycemia. 

How to take Rybelsus (semaglutide) prescription medicine

Your pharmacist will provide you with instructions on how to take your Rybelsus prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Rybelsus can come in different forms and doses, so follow the specific instructions on your prescription. It is typically prescribed once a day.

The usage instructions for Rybelsus are precise. It is crucial for the patient to carefully follow these instructions to ensure the medication works effectively and as expected. It is usually advised to take the medication with only a small amount of water.

This is usually done early in the morning to ensure the medication works throughout the day. The patient should also wait a certain amount of time before they consume breakfast after they use the drug - but it is essential not to skip breakfast. If you have trouble swallowing the prescription medicine, talk to your doctor about these oral medicines. Cushing or chewing the prescription medication is not advised if you have difficulty swallowing it.

What to avoid while taking Rybelsus (semaglutide)

Rybelsus can lead to specific drug interactions. Don’t change what you take without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

It is essential to be careful with beta-blocker drugs when taking Rybelsus. When you combine Rybelsus with certain beta-blockers, it may make it harder to identify a sudden fall in your blood glucose levels.

This is because the beta-blockers may prevent some of the symptoms, such as a fast heartbeat, that happens when you have hypoglycemia. Failure to recognize the early signs can lead to a more severe drop in your blood sugar levels. Be on the lookout for sweating, excessive hunger, and dizziness in these cases. These are also signs of low blood sugar. 

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Rybelsus.

Some research shows that regular alcohol consumption may cause changes in blood glucose levels. When the liver needs to metabolize alcohol, it may not work fast enough to process sugar. This can lead to a poor release of glucose into the blood, which can cause a drop in blood glucose levels. Thus, if you do not want to give up drinking, then make sure you limit your consumption of alcohol while you are taking Rybelsus. 

It is also essential to check any supplements you use when prescribed a daily dose of Rybelsus. Some herbal and dietary supplements may cause a reduction in blood glucose levels.

Combined with Rybelsus, this can significantly increase the risk of experiencing hypoglycemia. This also accounts for over-the-counter medicines. Some over-the-counter medicines may interact with the drug or affect your blood sugar levels. This may increase the risk of low blood sugar or other related complications.

If you have problems with your Thyroid C cell function or previously had Thyroid tumors, tell your doctor before you take Rybelsus. This is due to the risk of further Thyroid tumors associated with this medication. The doctor may monitor closely for Thyroid tumors or choose to use a different medicine to manage your blood sugar.

Talk to your doctor about other prescription drugs that you use. When your doctor understands the prescription and over-the-counter medicines you use, it is easier for them to check for drug interactions.

Alternative medications to Rybelsus

If your healthcare provider prefers to put you on another treatment, they may suggest another glucagon-like peptide-1 (GLP-1) agonist or an anti-diabetic medication in another drug class. The idea here is to find a prescription medicine that works for you. Here are some common doctor-recommended alternatives based on your health issue:

  • Insulin Resistance

    Insulin resistance is often considered an early stage that may lead to type 2 diabetes. Since Rybelsus is not a first-line treatment for type 2 diabetes, individuals with insulin resistance will likely receive a different medication as part of their treatment plan. 

  • Semaglutide Allergy

    An alternative must be considered for patients who require an antihyperglycemic drug that has experienced allergic reactions to Semaglutide, the active ingredient in Rybelsus. These may include: