Common side effects:
- Fatigue
- Mood swings
- Irritability
- Depression
- Memory loss
- Confusion
- Headaches

Levetiracetam is an anticonvulsant medication that treats different types of seizures, such as partial, myoclonic, and tonic-clonic seizures. The FDA approved Levetiracetam in 2000, and since, it has been used to treat young infants, children, and adults.2
Seizures occur when bursts of electricity zip through the brain and disrupt its normal functioning. In general, antiseizure medications decrease abnormal activity in the brain which helps to decrease the occurrence of seizures. Levetiracetam works in a different way than other seizure medications, but experts do not yet understand how.3 It is thought that the medication potentially binds to a special protein in the brain that mediates the release of neurotransmitters and regulates brain activity.
Levetiracetam is used to treat a wide range of seizures by itself and can be used in combination with other medications. It comes in pill, liquid, and intravenous form.3
Here at Plushcare, we cannot interpret EEG results, but here are some of the common seizures that Levetiracetam can treat.
The medication is used to treat partial-onset seizures in adults, children, and babies over one month old.3 Like their name suggests, partial-onset seizures, sometimes called focal seizures, stem from one part of the brain.7 They most commonly occur in the temporal lobes. Different medications, such as Levetiracetam or Lamotrigine, can be used to treat these forms of seizures.
Levetiracetam can be used with other drugs to treat generalized tonic-clonic seizures in people six years old and older. 2 These seizures, sometimes called grand mal seizures, are the most common seizures experienced by adults. They involve both tonic, which refers to stiffening, and clonic, which refers to twitching or jerking, phases of movement. These seizures usually cause loss of consciousness or at the very least, impaired awareness. They are also often feared by patients and families because they appear so severe. 8
Myoclonic seizures are short, uncontrollable muscle spasms that do not have an impact on your conscious awareness like other types of seizures. They are common among children with seizure disorders like juvenile myoclonic epilepsy.9 Levetiracetam has been approved as an add on treatment to treat myoclonic seizures in the US for adults and children over the age of 12.
Lennox-Gastaut syndrome is a severe version of epilepsy that usually starts before a child hits age 4.5 When you have this syndrome, you can have a range of several types of seizures that vary in frequency. Some might experience some seizure-free periods of life. The syndrome can also come with intellectual and cognitive difficulties. Some research suggests that Levetiracetam can help treat the myoclonic and generalized tonic-clonic seizures that can come with the syndrome. 10
Levetiracetam has been recommended as a first-line treatment against seizures for stroke patients. Some research also suggests that the medication can help prevent seizures in patients who have suffered from traumatic brain injuries. 13
Yes, Levetiracetam is the generic name for the medication Keppra. 11
Yes. Levetiracetam is approved for use in children and adults for various types of seizures.
As Levetiracetam can act as a depressant on the central nervous system, it might cause issues if taken with cannabis, alcohol, and opioids or other medications or substances that cause drowsiness.3 Otherwise, if you are taking macrogol, a laxative, or methotrexate, a medicine for arthritis, your doctor might adjust your dose of Levetiracetam. 12
Miss a dose? Take it when you remember. If you must take your next dose in 12 hours, it is best to skip it and wait. It is not recommended to take two doses at the same time, or an extra dose to make up for medication that you have missed. 12 Consider talking to your doctor if you frequently miss doses to see if there can be adjustments to your treatment plan.
You can take Levetiracetam during pregnancy. Experts recommend taking high doses of folic acid if you have become pregnant on Levetiracetam. 12
Levetiracetam has a different chemical profile than other seizure drugs. It is a popular antiseizure medication because it typically causes fewer side effects than many anticonvulsants on the market and pairs well with other drugs. 3
PlushCare physicians can refill seizure medications for stable patients. We will discuss your seizure history and medication regimen and consider if an evaluation with laboratory tests is appropriate. We can also provide counseling on seizure precautions and common triggers. Evaluations of new seizures or changes in seizure history often require the input of a specialist like a neurologist and we can assist with a referral if appropriate.


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At the doctor's discretion we can refill seizure medications for stable patients and send prescriptions to your local pharmacy.
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