Rocephin (ceftriaxone) prescription available online 

If you are suffering from bacterial infections, Rocephin can help. Get a new prescription or refill of Rocephin from a board-certified doctor online.

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Book an appointment

If you are suffering from bacterial infections, Rocephin can help. Get a new prescription or refill of Rocephin from a board-certified doctor online.

Medication services available for adults and kids (3+)

Top-quality, board-certified doctors

Insurance accepted, but not required

Prescriptions sent to your local pharmacy*

*Prescriptions provided at the doctor’s discretion

We accept these insurance plans and many more!

Most patients with in-network insurance pay $30 or less. Paying without insurance? New patient visits are $129, and follow-ups are only $99 for members.

Don’t see your provider listed? Email [email protected]  or call  (888) 564-4454  to talk to a PlushCare specialist.

3 simple steps to request your Rocephin prescription today 

Step 1

Book a Rocephin prescription request appointment.

Book a same day appointment from anywhere.

Step 2

Talk to your medical provider regarding your Rocephin prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Rocephin prescription.

We can send prescriptions to any local pharmacy.

Rocephin prescription pricing details

How pricing works

To get a new or refill on your Rocephin prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free

First visit


For all visits

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free

First visit


Repeats only $99

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129 and follow-ups are only $99 for active members.

Book an appointment

If we're unable to treat you, we'll provide a full refund.

Rocephin prescription FAQs

  • How much does Rocephin cost?

    You will find that the costs associated with Rocephin can greatly differ between pharmacies. You also have to consider whether you are going to use the brand name or, rather, the generic form of the medication. Tell your doctor or pharmacist if you have a preference for one in particular.

  • How can I refill my Rocephin prescription?

    Rocephin will not be used for extended periods of time. It is a medication used for a short period to assist in the treatment of bacterial meningitis, as well as other bacterial infections. Thus, you will likely not need to refill a prescription for the medication.

  • What precautions should be taken when taking Rocephin?

    Do not combine this medication with other drugs that also fight against bacterial infections, such as beta-lactam antibacterial agents. You may experience a severe intestinal condition or other adverse effects if you combine multiple antibiotic medications. Tell your doctor if you have a serious blood problem, as this medication can cause blood cell disorders. You should also be careful about using an intramuscular dose of Rocephin if you have severe renal impairment.

  • How long are you contagious after Rocephin?

    Bacterial infections are often not contagious in the same way in viral infections are. It does, however, depend on the specific condition that you treat with the ceftriaxone concentrations in your body. For example, certain sexually transmitted bacterial infections may remain contagious for a couple of days after you start to use this medication to treat the condition. In other cases, the spreading of the bacteria that causes the infection is often not a concern.

  • Is one shot of Rocephin enough?

    It largely depends on the condition that is being treated. The doctor first needs to consider how severe the bacterial infection is. With milder bacterial meningitis or other related conditions, a single shot may be given. You will then be monitored to see how your symptoms are. If your symptoms disappear and certain lab tests show no signs of a bacterial infection, you may not require additional shots of the medicine. There are, however, several cases where you may need to go for another intramuscular dose after the initial one.

  • Who should not take Rocephin?

    Rocephin is not appropriate for people with certain blood disorders. It is also not a good choice for individuals who currently use prescription drugs that have drug interactions with Rocephin. Pregnant women should be careful as the medication may affect parenteral nutrition when the medication passes to the fetus.

  • What happens if I miss a dose of Rocephin?

    It is crucial to ensure you do not have a missed dose of Rocephin. This may cause the infection to come back. In some cases, the reappearance of the infection may be worse than it was initially.

  • What happens if I take too much Rocephin?

    Too much Rocephin can cause potentially fatal complications. It raises the risk of serious adverse effects associated with the drug. Fortunately, doctors often administer Rocephin themselves, which can help to significantly reduce the risk of overdosing on the medication.

About Rocephin 

Rocephin is considered a cephalosporin antibiotic, which functions by fighting against the presence of certain bacterium species in your body. Like any antibiotic, this medication can only be used for bacterial infections. It is ineffective against viral or fungal infections because it will not kill the microorganisms that cause them.

Some conditions that Rocephin is known to treat include meningitis, pneumonia, and E. coli. Rocephin is available only by prescription. It is available in a generic formulation as well as under different brand names, including ceftriaxone.

Rocephin may be prescribed as an injection or through intravenous (IV) administration. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage that you are prescribed.

If you are prescribed Rocephin, be sure to complete the full course of the antibiotic unless your doctor specifically tells you to stop.

If you don’t complete your prescription, the cephalosporin antibiotic may not fully treat your bacterial infection.

IV infusion is usually given at medical and lab appointments. This ensures a healthcare professional or qualified nurse can assist when administered intravenously. It also ensures there is a healthcare professional available should severe cutaneous adverse reactions occur during the infusion process. Medical and lab appointments may also be used in cases where the patient obtains these cephalosporin antibiotics through an injection into muscle tissue. The medication should not be mixed with calcium containing solutions. Even though dilution is generally advised, calcium containing solutions may cause problems with the infusion process or lead to adverse effects. This is partly due to the ceftriaxone calcium salt that is used in the preparation and usage instructions of the medication.

Rocephin uses

There is one main FDA-approved use for Rocephin, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons. It’s also possible that your health care provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Bacterial infections

    Rocephin is a calcium containing medicine that is classified among the cephalosporin antibiotics class. Certain lab tests may be required before these prescription drugs are provided to the patient. A ceftriaxone injection is usually given at the doctor's office as part of antibiotic treatment. It is very uncommon to find resistance to these antibiotics. In cases where resistance is noted, it is usually related to penicillin binding proteins.

    Rocephin is not meant for prolonged or repeated periods of treatment. This may cause an increased risk of antibiotic resistance, possible drug interactions, and serious side-effects. Very serious side effects can occur when long-term use leads to resistance, which can cause complicated urinary tract infections and other bacterial infections to occur in the patient's body.

    The dosage of this medication is given in mg/ml and largely depends on factors like the patient's current condition, the increased risk factors they may face for adverse effects, and their age.

    Some bacterial infections that are sometimes treated with and intramuscular injection or administered intravenously using Rocephin include:

    • Bacterial meningitis

    • Pelvic inflammatory disease

    • Otitis media (ear infections)

    • Prosthetic joint infection

    • Pneumonia

    • E.coli infections

    If the patient is advised to use the injectable solution at home, then they need to ensure they know how to discard medical supplies safely. The patient will also be educated on the preparation and usage instructions. This ensures they understand how to safely use the needles and Rocephin vials. A local waste disposal company can be used when throwing away the used needles.

Rocephin side effects

The side effects associated with taking Rocephin are typically mild to moderate.

  • Rocephin has some common side effects. They may include:

    • Diarrhea

    • Rashes

    • Lump at the injection site

    • Vaginal discharge

    • Vaginal itching

    Some people may develop symptoms associated with blood cell disorder. It is important to look out for these symptoms and to tell your doctor or pharmacist if you experience them. Certain lab tests may be done in order to confirm whether you experience a blood cell disorder as a complication of the antibiotic treatment.

    Other side effects, which are less common but might be more severe, could include:

    • Severe abdominal pain

    • Diarrhea

    • Blood in stool

    • Severe nausea and vomiting

    • Yellow skin

    • Dark urine

    • Severe hypersensitivity reactions

    • Kidney problems

    • Bladder problems

    • Breathing problems

    Patients should also note that kidney function tests and liver function tests may show abnormal results while they use the medication.

    You should call your doctor if you notice any of these side effects, or if you develop any other new or concerning symptoms. Discard medical supplies safely and do not reuse a needle more than once. This may cause problems with the injection site or inject more microorganisms into your body.

    Apart from these, patients also need to look out for allergic reactions. When there are allergic reactions following the use of ceftriaxone sodium, the patient may experience trouble breathing, hives, and other adverse effects. Very serious side effects of an allergic reaction can cause serious symptoms that require immediate medical attention.

How to take Rocephin

Your pharmacist will provide you with instructions on how to take your Rocephin prescription.

Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Rocephin can come in different forms and doses, so be sure to follow the specific instructions on your prescription. You will usually receive Rocephin vials and injections in order to perform an intramuscular injection. You may ask your doctor or pharmacist to do the injection for you. Intravenous injection is done only at a healthcare professional's office.

Never inject more of the medicine that is prescribed, as it will not help to kill the bacteria and take care of the infection faster. A high dose may require a visit to your local poison control center. This is due to the toxicity that it may induce when high concentrations of prescription drugs enter your body.

What to avoid while taking Rocephin

Rocephin has a number of drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs.

Do not use this medication with other calcium-containing solutions. You should also tell your doctor about any other prescription drugs you use. Be careful about breastfeeding while using Rocephin. Tell your doctor if you are currently breastfeeding, as they can determine if Rocephin is a safe choice for you and your baby.

You also have to list all prescription drugs that you are on to help your doctor identify possible drug interactions. Make sure you also mention any nonprescription drugs you use, such as over-the-counter medicines or herbal products. There are certain cases where these can also lead to drug interactions. Certain drug interactions may lead to occasionally fatal hypersensitivity reactions, serious blood problems, and other problems.

If you have a medical history of antibiotic allergies, tell your doctor. They can first do a test to determine if you are allergic to ceftriaxone sodium or another form of the drug that they would like to use.

Ask your doctor or pharmacist if it is acceptable to consume alcohol while taking Rocephin.

Medication alternatives to Rocephin

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another cephalosporin antibiotic or an antibiotic in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Mild bacterial infection

    Not every bacterial infection is the same in terms of severity. Sometimes, intramuscular ceftriaxone may produce too many risks compared to the severity of the condition. If you only have a mild infection, then your doctor could suggest the use of another antibiotic - often one with a lower side effect profile. A milder antibiotic may also be used initially before intravenous doses of ceftriaxone solutions are provided.






Rocephin prescription resources