Cabenuva (Cabotegravir) prescription available online today 

If you are suffering from HIV, Cabenuva can help. Get a new prescription or refill of Cabenuva today from a board-certified doctor online.

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Two separate injections administered by healthcare professional

FDA-approved to treat HIV

Take control of your sexual health

*Prescriptions are provided at the doctor’s discretion. Learn more about our controlled substances policy and how you can save up to 80% with our prescription discount card.

About Cabenuva 

Cabenuva is an injection kit containing cabotegravir and rilpivirine in separate single-dose vials. Cabotegravir and rilpivirine are both antiviral medications that prevent human immunodeficiency virus (HIV) from multiplying in your body.

Cabenuva can be used to treat HIV in people who are taking a current antiretroviral regimen with viral suppression. Cabenuva is available only by prescription. It is available in a generic formulation as well as under different brand names, including cabotegravir and rilpivirine.

Cabenuva may be prescribed as an injection kit. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Cabenuva, be sure to complete the full course of the HIV medicines unless your doctor specifically tells you to stop. If you don’t complete your prescription, the HIV medicines may not fully treat your HIV infection.

Cabenuva uses

There is one FDA-approved use for Cabenuva, but it may also be used off-label to treat other conditions. Your online medical professional may prescribe it for any of the following common reasons.

It’s also possible that your healthcare provider may prescribe it for other reasons not listed here. If you have questions about why a medication is prescribed, ask your online doctor or pharmacist.

  • Human immunodeficiency virus (HIV)

    Cabenuva is FDA-approved to treat HIV in people living with HIV. Cabenuva is a long-acting injectable HIV regimen that contains two HIV drugs: cabotegravir, an integrase strand transfer inhibitor, and rilpivirine, an extended-release injectable.

    Cabenuva is an approved maintenance therapy for adults who have achieved viral suppression on a stable antiretroviral regimen and who have no history of treatment failure and no known suspected viral resistance to either cabotegravir or rilpivirine.

    Cabenuva is not a cure for HIV or AIDs, and Cabenuva should not be used for HIV prevention.

Cabenuva side effects

  • The side effects associated with taking Cabenuva are typically mild. Most Cabenuva side effects are associated with post-injection reactions. Cabenuva has some common side effects. Common adverse reactions may include:

    • Injection site reactions (pain, redness, swelling, or bruising around the injection site)

    • Musculoskeletal pain

    • Feeling tired or sleep problems

    • Fever

    • Nausea

    Other side effects, which are less common but might be more severe, could include:

    • Unusual changes in mood or behavior

    • Serious post-injection reactions, such as severe hypersensitivity reactions

    • Suicidal thoughts or behaviors

    • Allergic reactions

    • Signs of liver problem

    You should call your doctor if you notice adverse reactions, or if you develop any other new or concerning symptoms. The use of Cabenuva is approved in young children over 12 years of age and weighing at least 77 pounds to replace current antiretroviral medications.

How to take Cabenuva

Your pharmacist will provide you with instructions on how to take your Cabenuva prescription. Be sure to read your prescription label and follow the instructions. Call your doctor or pharmacy if you have any questions.

Cabenuva can come in different forms and doses, so be sure to follow the specific instructions on your prescription. At least 28 days before your first injection, you'll start taking cabotegravir and rilpivirine in tablet forms once daily with food.

On your last day of oral lead-in medication, you'll receive your first injection dose. Cabenuva is an intramuscular injection given either once per month or once every two months. Your healthcare provider will give you the medication as two separate injections.

One month after your first injected dose, you'll begin regular monthly Cabenuva injections. Healthcare professionals will observe patients briefly after each injection to ensure no hypersensitivity reactions develop.

What to avoid while taking Cabenuva

Cabenuva has 420 drug interactions. Don’t change what you are taking without checking with your doctor or pharmacist. That includes other medications or supplements, as well as over-the-counter drugs. 

Potentially significant drug interactions with Cabenuva include:

  • Other medications used to treat HIV

  • St. John's wort

  • Certain antibiotics, including clarithromycin, erythromycin, and rifampin

  • Seizure medication, including carbamazepine, oxcarbazepine, and phenobarbital

  • Viekira Pak

  • Palutamide, dexamethasone, and enzalutamide

Consuming grapefruit or grapefruit juice can increase the blood plasma concentration of Cabenuva. Avoid consuming grapefruit while taking Cabenuva injections.

Drinking alcohol while taking Cabenuva can lead to an increased risk of liver damage.

Medication alternatives to Cabenuva

If your healthcare provider prefers to put you on another treatment altogether, they may suggest another stable antiretroviral regimen or HIV medicine in another drug class. Here are some common doctor-recommended alternatives based on your health issue:

  • Human immunodeficiency virus (HIV)

    Trogarzo (ibalizumab)

    Fuzeon (enfuvirtide)

    Apretude (cabotegravir extended-release injectable suspension)

Cabenuva prescription FAQs

  • How much does Cabenuva cost?

    Depending on your pharmacy, Cabenuva costs around $4,390 for 4 mL of extended-release suspension (200 mg-300 mg/mL) without insurance. Fortunately, generic brands, such as cabotegravir and rilpivirine, offer an affordable alternative.

  • How can I refill my Cabenuva prescription?

    To refill your Cabenuva prescription, book a virtual appointment with a board-certified PlushCare doctor. After reviewing your medical history, your doctor can send an electronic prescription to your local pharmacy.

  • Who should not take Cabenuva?

    Avoid taking Cabenuva if you have certain medical conditions, such as:

    • Long QT syndrome

    • Previous hypersensitivity reaction to cabotegravir or rilpivirine

    • Underlying liver disease, including hepatitis B or C

    • Known or suspected resistance to cabotegravir or rilpivirine

    • Mental illness, including depressive disorders

  • Can patients self-administer Cabenuva?

    No, Cabenuva cannot be self-administered. Cabenuva is a long-acting medication administered by your healthcare provider as two separate injections.

  • Do you refrigerate Cabenuva?

    Yes, Cabenuva should be refrigerated. Cabenuva needs to be brought to room temperature prior to injection and is stable at room temperature for up to six hours.

  • How long does Cabenuva stay in your system?

    Cabenuva is a long-acting medicine that stays in your body for 12 months or longer after your final injection doses.

  • What happens if I miss a dose of Cabenuva?

    If you miss an appointment for a Cabenuva injection by more than seven days, you may need to take cabotegravir and rilpivirine tablets daily until your next injection.

  • What happens if I take too much Cabenuva?

    Because Cabenuva is administered by your healthcare provider, you're unlikely to overdose.

3 simple steps to request your Cabenuva prescription today 

Step 1: Book an appointment

Step 1

Book a Cabenuva prescription request appointment.

Book a same day appointment from anywhere.

Step 2: Visit with a doctor on your smartphone

Step 2

Talk to your medical provider regarding your Cabenuva prescription.

Visit with a doctor on your smartphone or computer.

Step 3: pick up at local pharmacy

Step 3

Pick up your Cabenuva prescription.

We can send prescriptions to any local pharmacy.

Cabenuva prescription pricing details

How pricing works

To get a new or refill on your Cabenuva prescription, join our monthly membership and get discounted visits.

Paying with insurance



First month free

First visit


For all visits

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance



First month free

First visit


Repeats only $99

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129 and follow-ups are only $99 for active members.

Book an appointment

If we're unable to treat you, we'll provide a full refund.


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