Sofie Wise

Ryan Quinn

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About Author — Ryan has a background in geochemical research and enjoys writing on technical subjects like health and science. He lives in Salt Lake City, UT and can be found recreating in the local mountains.

Most PlushCare articles are reviewed by M.D.s, Ph.Ds, N.P.s, nutritionists and other healthcare professionals. Click here to learn more and meet some of the professionals behind our blog.

Can You Get a Premarin Prescription Online?

At PlushCare we can write and refill prescriptions online. We can also help you find a safe online pharmacy where you can buy Premarin online.

What is Premarin and What Does it Treat?

Premarin is a brand name for conjugated estrogens, a hormone replacement medication for people in need of estrogen.

Premarin is used to treat:

  • Menopause. Taking Premarin can help with menopause symptoms by reducing hot flashes and the chance of getting osteoporosis (bone loss). Premarin also helps treat changes in and around the vagina that cause painful sex after menopause (primarily drying and thinning of vaginal tissue).
  • Ovarian failure (loss of normal function of the ovaries).
  • Breast or prostate cancer (yes, men are sometimes prescribed Premarin).

How Does Premarin Work?

Premarin works by replacing the estrogen no longer produced by the body. The body absorbs estrogen replacements in Premarin and uses them towards heart health, bone health, mood management, and sexual function in the same way the body uses estrogen.

The active ingredients in Premarin are derived from the urine of pregnant horses.

Premarin Dosage and Treatment

Premarin comes in several forms. It is usually administered as a tablet taken once-daily, with or without food.

For treating menopause, doctors begin with a low daily dose (0.3 mg) that is gradually increased. This is done so that symptoms can be treated with as little medication as possible.

Vaginal cream can be used for more specific treatment (vaginitis as well as thinning and drying of vaginal tissues). Vaginal cream also begins with a low dose (0.5 g) and is increased (up to 2 g) gradually. It is administered cyclically: 21 days on, followed by 7 days off. Premarin cream is inserted directly into the vagina.

For cancer treatment, liquid Premarin is either injected into veins or large muscles.

The appropriate Premarin dosage depends on what condition is being treated. Always follow the directions given by your doctor for proper dosage.

Benefits of Premarin

Premarin can help menopausal and postmenopausal women by reducing hot flashes, vaginal dryness, and night sweats. Treating these symptoms can help individuals sleep better and engage in sexual intercourse without pain. Premarin also helps prevent bone loss from osteoporosis, helping women to maintain strong and healthy bones.


Side Effects of Premarin

Chances of experiencing side effects can be reduced by taking the proper dosage. Do not share medications with other people even if they have the same symptoms.

Less serious but common side effects of Premarin:

  • Headache
  • Breast pain
  • Irregular vaginal bleeding or spotting
  • Stomach cramps
  • Bloating
  • Nausea and vomiting
  • Hair loss
  • Fluid retention
  • Vaginal yeast infection

Serious but less common side effects of Premarin include:

  • Heart attack
  • Stroke
  • Blood clots
  • Dementia
  • Breast cancer
  • Endometrial cancer
  • Ovarian cancer
  • Hypertension
  • High blood sugar
  • Gallbladder disease
  • Liver problems
  • Enlargement of fibroids
  • Severe allergic reactions

Contact a doctor right away if you experience any of the following:

  • Breast lumps
  • Unusual vaginal bleeding
  • Vision or speech changes
  • Sudden and severe headaches
  • Severe pains in the chest or legs accompanied by weakness and fatigue
  • Swollen lips, tongue, face, hands, ankles, or feet.
  • Yellowing of skin or eyes

Considerations and Precautions of Premarin

For women with a uterus, Premarin increases the chance of endometrial cancer. Taking progestin along with Premarin reduces the risk.

Due to the side effects, patients taking Premarin should visit their doctor on a regular basis and have regular mammograms.

Before taking Premarin you should inform your doctor of any allergies. Also talk to them about your medical history, particularly anything similar to Premarin side effects.

Smoking tobacco combined with conjugated estrogens significantly increases the risk of stroke, blood clots, hypertension, and heart attack.

This medication should not be taken by pregnant women or women who are breastfeeding. If pregnancy occurs discontinue use immediately.

People taking Premarin should avoid alcohol and grapefruit juice.

There are numerous interactions with other medications and herbal supplements (e.g. St. John’s Wort) that can be serious. Tell your doctor about medications or herbal supplements you take before taking Premarin.


Can You Buy Premarin Online?

You can buy Premarin online, but take caution. There are many safe and legal online pharmacies, but there are also many untrustworthy and dangerous ones. The FDA has a guide for buying medications online safely.

Rogue pharmacies sell medications that are not approved or are possibly counterfeit. Such unapproved and fake medications are dangerous due to:

  • Incorrect dosages
  • Incorrect active ingredients
  • Improper storage
  • Unexpected and unpredictable drug interactions
  • Unknown side effects
  • Containing harmful ingredients

Warning signs of a rogue online pharmacy:

  • They sell prescription medicines without requiring a prescription.
  • They sell prescription medications at a substantially discounted price.
  • Send you unsolicited marketing the emails.
  • Are located outside of the US, do not have a US license pharmacist available for help, and ship worldwide.

Luckily, there are reputable sites like PlushCare where you can have a video or phone appointment with a trusted doctor who will discuss your medical concerns and current medications and decide if Premarin or another medication is the best option for you.

To talk to one of our experienced doctors, just click here or call (888) 660-5348 to schedule an online appointment to discuss whether you would benefit from Premarin. If the doctor believes that Premarin is good for you, they will electronically send your prescription to your local pharmacy, where you can pick it up when it’s ready. It’s that easy to buy Premarin online!

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