Premarin (conjugated estrogens) vaginal cream prescription available online

Premarin vaginal cream is clinically proven to relieve moderate to severe painful sex after menopause by rebuilding vaginal tissue to make intercourse more comfortable. There is no generic equivalent, so consult with our doctors today and get a new prescription or refill of Premarin today.

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Learn about Premarin vaginal cream 

Premarin vaginal cream is considered a conjugated estrogens cream, which contains a mixture of estrogen hormones. Conjugated estrogens help treat changes in and around the vagina, such as dryness, itching, and burning in postmenopausal women. It can also help treat vaginal pain during sexual intercourse.

Premarin vaginal cream is available only by prescription. It’s always important to follow the specific instructions on your prescription, as they can vary based on the formulation and dosage prescribed.

If you're prescribed Premarin, complete the course unless your healthcare provider specifically tells you to stop. If you don’t complete your Premarin prescription, it may not fully treat your symptoms.

Premarin vaginal cream uses

  • There is 1 FDA-approved use for Premarin vaginal cream, but your healthcare provider may also prescribe it off-label to treat other medical conditions. Some common uses of Premarin vaginal cream include:

    1. Treatment of vaginal dryness: Menopause can cause a decrease in estrogen levels, which can result in vaginal dryness. Premarin vaginal cream can help to restore the natural moisture and elasticity of the vaginal tissues, reducing discomfort and pain during sexual activity.

    2. Treatment of vaginal atrophy: As estrogen levels decline during menopause, the tissues of the vagina may become thin and less elastic. This can lead to vaginal atrophy, which can cause pain during sexual activity, urinary incontinence, and urinary tract infections. Premarin vaginal cream can help to restore vaginal tissues and reduce these symptoms.

    3. Prevention of osteoporosis: Estrogen is essential for maintaining bone density, and menopause can lead to a loss of bone mass. Premarin vaginal cream may be prescribed to help prevent osteoporosis in women who are at high risk.


    Talking to your doctor about the risks and benefits of using Premarin vaginal cream is important, as it may not be appropriate for everyone. Your doctor can help you determine if this medication is right for you and provide guidance on how to use it safely and effectively.

Premarin vaginal cream side effects

The side effects associated with taking Premarin vaginal cream are typically mild. Most Premarin side effects are associated with breast pain, headaches, and pelvic pain.

Premarin vaginal cream has some common side effects. They may include:


  • Other side effects, which are less common but might be more severe, could include:


    You should call your healthcare provider if you notice any of these side effects or if you develop any other new or concerning symptoms. Report any unusual vaginal bleeding right away. Premarin vaginal cream is not recommended in children under 12 years of age.


    Using estrogen-alone may increase your risk of several health problems, including:

    • Heart attacks

    • Strokes

    • Breast cancer

    • Endometrial cancer

    • Cancer of the uterus

    • Blood clots


    Because of these risks, your healthcare provider will prescribe estrogen at the lowest effective dose to relieve your symptoms.

How to use Premarin vaginal cream

Your pharmacist will provide you with instructions on how to take your Premarin vaginal cream prescription. Be sure to read your prescription label and follow the instructions. Call your healthcare provider or pharmacy if you have any questions. The following general guidelines can help you understand how to use this medication:

  1. Wash your hands thoroughly with soap and water before using the cream.

  2. Remove the cap from the tube of Premarin vaginal cream.

  3. Attach the applicator to the open end of the tube.

  4. Squeeze the tube to fill the applicator with the prescribed amount of cream. Your healthcare provider will give you specific instructions on how much and how often to use it.

  5. Lie on your back with your knees bent, or stand with one foot on a chair or other elevated surface.

  6. Gently insert the applicator into the vagina as far as it will comfortably go.

  7. Press the plunger of the applicator to release the cream.

  8. Remove the applicator and dispose of it in the trash.

  9. Wash your hands thoroughly with soap and water after using the cream.

  10. Store the tube of Premarin vaginal cream at room temperature, away from heat and light.


It is important to follow your healthcare provider's instructions for using Premarin vaginal cream and to use it only as prescribed. Contact your healthcare provider immediately if you experience any unusual symptoms or side effects while using this medication.

What to avoid while using Premarin vaginal cream

Premarin has 213 drug interactions. Don’t change what you are taking without checking with your healthcare provider. That includes other medications, supplements, and over-the-counter drugs. There are some things you should avoid while using Premarin vaginal cream. Here are some general guidelines:

  1. Do not use other vaginal products at the same time as Premarin vaginal cream unless your healthcare provider has specifically instructed you to do so. Using other vaginal products (such as douches, spermicides, or other creams) at the same time as Premarin vaginal cream may interfere with its effectiveness.

  2. Avoid sexual activity immediately after using Premarin vaginal cream. The cream may weaken latex condoms and diaphragms, making them less effective.

  3. Avoid using Premarin vaginal cream if you have a history of certain medical conditions, such as breast cancer or a history of blood clots. Talk to your healthcare provider about your medical history before using this medication.

  4. Avoid using Premarin vaginal cream during pregnancy or while breastfeeding unless your healthcare provider has specifically instructed you to do so.

  5. Avoid getting Premarin vaginal cream in your eyes, nose, or mouth. If this occurs, rinse the affected area thoroughly with water.

  6. Avoid storing Premarin vaginal cream in temperatures above 86°F (30°C), as this may cause the medication to break down and become less effective.


It is important to follow your healthcare provider's instructions for using Premarin vaginal cream and to talk to them about any questions or concerns you may have about the medication.

Medication alternatives to Premarin vaginal cream

Several medication alternatives to Premarin vaginal cream for treating vaginal dryness, itching, and burning associated with menopause. Some of these alternatives include:

  • Vaginal estrogen creams

    Like Premarin vaginal cream, other vaginal creams contain estrogens, such as Estrace, Estring, and Vagifem. These medications are also applied directly to the vagina and work to restore vaginal moisture and elasticity.

  • Vaginal moisturizers

    Unlike vaginal estrogen creams, vaginal moisturizers do not contain estrogen. Instead, they are water-based products designed to provide long-lasting moisture to the vaginal tissues. Examples include Replens, Luvena, and KY Liquibeads.

  • Systemic hormone therapy

    In addition to vaginal estrogen therapy, some women may benefit from systemic hormone therapy (HT), which involves taking estrogen as a pill, patch, or gel. However, systemic HT is not recommended for all women, as it may increase the risk of specific health problems, such as blood clots, stroke, and breast cancer.

  • Non-hormonal treatments

    Several non-hormonal treatments may also be effective for treating vaginal dryness, such as vaginal lubricants, vaginal dilators, and certain medications, such as ospemifene.



    It is essential to talk to your healthcare provider about the risks and benefits of these medication alternatives and any other treatment options that may be appropriate for your needs. They can help you determine the best course of treatment based on your medical history, symptoms, and preferences.

Premarin vaginal cream prescription FAQs

  • When is the best time to use Premarin vaginal cream morning or night?

    It's best to use Premarin vaginal cream at night. Since you'll be laying down after the application, you won't have to worry about excess leakage.

  • How long does Premarin vaginal cream take to work?

    Premarin vaginal cream can provide relief in as little as four weeks. However, it may take up to 12 weeks to see the full effect of your Premarin prescription.

  • How many doses are in 14 g of Premarin vaginal cream?

    Although dosage will vary depending on your symptoms, approximately 28 doses are in 14 g of Premarin vaginal cream. The initial starting dose for Premarin is 0.5 g/day.

  • What is a generic drug for Premarin vaginal cream?

    The generic drug for Premarin is conjugated estrogens or estrogen vaginal cream.

    If you're on a government health insurance plan or federally funded insurance program, generic conjugated estrogens may come with a lower out-of-pocket cost than the brand-name prescription drug. Pharmacy benefit programs can also help you get maximum savings on your prescription costs.

  • What happens if I take too much Premarin vaginal cream?

    If you've taken too much Premarin, call your healthcare provider immediately. The estrogen overdose may cause nausea, breast pain, fatigue, and withdrawal bleeding (bleeding after menopause).

3 simple steps to request your Premarin vaginal cream prescription today 

Step 1

Book a Premarin vaginal cream prescription request appointment.

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Step 2

Talk to your medical provider regarding your Premarin vaginal cream prescription.

Visit with a doctor on your smartphone or computer.

Step 3

Pick up your Premarin vaginal cream prescription.

We can send prescriptions to any local pharmacy.

Premarin vaginal cream prescription pricing details

How pricing works

To get a new or refill on your Premarin vaginal cream prescription, join our monthly membership and get discounted visits.

Paying with insurance

Membership

$16.99/month

First month free

Visits

Copay

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price with insurance

Often the same as an office visit. Most patients with in-network insurance pay $30 or less!

  • We accept these insurance plans and many more:

    • Humana
    • Aetna
    • United Healthcare

Paying without insurance

Membership

$16.99/month

First month free

Visits

$129

30 days of free membership

  • Same-day appointments 7 days a week

  • Unlimited messages with your Care Team

  • Prescription discount card to save up to 80%

  • Exclusive discounts on lab tests

  • Free memberships for your family

  • Cancel anytime

Visit price without insurance

Initial visits are $129.

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If we're unable to treat you, we'll provide a full refund.

Premarin Vaginal cream prescription resources

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