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Leah McCabe

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About Author — Leah likes writing about health and science subjects. Through her writing she hopes to help people of all backgrounds have equal access to information and quality healthcare.

Most PlushCare articles are reviewed by M.D.s, Ph.Ds, N.P.s, nutritionists and other healthcare professionals. Click here to learn more and meet some of the professionals behind our blog.

Antidepressant Medication Reviews


Warning: The use of certain antidepressants to treat major depressive disorder (MDD) in adolescents may increase the risk of suicidal ideations and behaviors. While taking antidepressants mental health can change in unexpected ways. You should call a doctor right away if you experience any suicidal thoughts. Always talk to a doctor about the risks and benefits of taking antidepressant medication before beginning treatment.


When talking about your health, it’s important to understand that taking care of your mental health is just as important as taking care of your physical health. Mental health is often ignored as physical health takes the forefront. While supporting physical conditions like heart health, nutrition, and exercise is crucial, mental healthcare is just as important.

If you are suffering from anxiety or depression, there are many antidepressant options on the market today that may support your treatment plan. Talk to your doctor or psychiatrist to see if antidepressants may be beneficial to you.

We’re breaking down the top most commonly prescribed antidepressant medications, as well as sharing some reviews. With this information, you can gather some background information to bring to your next doctor’s appointment to discuss your own unique medication needs. 

Prozac

Prozac is an SSRI medication (selective serotonin reuptake inhibitor). The generic name is fluoxetine. It works by affecting certain chemicals in the brain that may help support the treatment of depression, anxiety, OCD, panic disorders, bulimia nervosa, and is commonly used to treat major depressive disorder. 

Prozac Reviews 

From drugs.com, here are user reviews of Prozac 

11/20/19 

“I was started on this medication at a very low dose in college…I suffer from depression & anxiety; after a few weeks the depression started to slowly go away-minimal side effects mainly less energy. I have been on and off it/trying other options since then & nothing has helped as much. Zoloft & Paxil did not have an impact. I stopped taking it after feeling better for a long time but my depression came back and was much worse, now finally getting it under control. I personally don’t like taking any medicine but this one has helped me a great deal-the side effects (especially being really tired) at least for me went away after the first month. I hope if you are reading this, with medicine or not you are well and taking the best care of yourself possible =)”

11/7/19

“I’m on 80mg of prozac and it has been a lifesaver for me. I went off at one time but my depression and anxiety came back with a vengeance..I just started taking it again last week at the 80mg dose and I already am starting to feel like myself. The only side effect I don’t like is the heartburn so you have to drink a big glass of water when you take it, otherwise you feel like your esophagus is on fire. I’ve had no other negative side effects. It also helped me quit smoking and my craving for sweets. I’m sticking to this med forever..”

10/26/19

“This is the worst prescription medicine for anxiety I’ve ever had. I used it for 6 months and it made my anxiety way way worse I can’t go anywhere anymore not even leave my house.”

Zoloft

Zoloft, also known as sertraline is another SSRI antidepressant medication that is commonly prescribed to treat depression, OCD, anxiety, panic disorders, post-traumatic stress disorder, and premenstrual dysphoric disorder

Zoloft Reviews 

From drugs.com, here are user reviews of Zoloft 

11/17/19

“I was prescribed 50mg of Zoloft, about an hour after taking this medicine I started to feel extremely anxious and almost a jittery feeling and couldn’t seem to sit still, about two hours later that seemed to settle but I became very nauseated and had to make frequent trips to the rest room…. soon after I became extremely irritable, literally EVERYTHING and everyone was getting on my nerves, around 5PM I became extremely anxious AGAIN and couldn’t sit down, my heart was racing and my mind was all over the place… “

11/14/19

“I’ve been dealing with anxiety and intrusive thoughts pretty much my whole life. After my first baby, my anxiety got really bad. The sleepless nights didn’t help and the general stress of it all. I had never taken an antidepressant because I was a very happy person aside from my anxiety. Once I started Zoloft it took about a month for me to feel the affects. I’m currently on 50 mg of Zoloft and my anxiety is so much better. I wake up so much happier and now, I can focus on being a good mom and being present. I really recommend this to anyone who is dealing with anxiety and obsessive thinking. Just to note, don’t stop taking the medication if your anxiety increases. The first few weeks were really hard. It’s just your mind adjusting to the drug and playing tricks on you. Stick with it. I promise it really helps.”

10/28/19

“I already have issues with sadness and irritability. And taking this made both even worse. Also had a lot of weird eye twitching.”

Lexapro

Lexapro, or escitalopram, is an SSRI commonly prescribed to treat anxiety as well as major depressive disorder. 

Lexapro Reviews 

From drugs.com, here are user reviews of Lexapro 

11/19/19

“I am on my 3rd day. I called Dr today thinking I wanted to stop the first 2 days were not good. I felt like I had flu. I still am not sleeping but she said stay on it give it at least 2 weeks. All of a sudden I took a turn and think it truly is working I will stay in touch “

11/12/19

“I promised myself if i made it out alive I’d come back and give my review, I’ve been on the meds a little over 2 months and the outcome has been very well for me! First couple of weeks are ruff but stick it out it’ll be well worth it!”

11/21/19

“I have been dealing with anxiety for a few months now. Initially went to the ER a few times not know what it was. Then was told it could be anxiety and took Lorazepam (prescribed from the ER doctor) which worked amazingly! Then went to a primary care doctor and was prescribed 10mg of this medication Lexapro. After 2 hours of taking the medication I had a terrible panic attack with a fast heartbeat, super fatigued, dizziness, sweats and a little lethargic. The doctor wanted me to cut the pill and half and continue taking it but I am way too afraid and would rather not deal with those side effects and just deal with my anxiety and self heal.”

Paxil

Paxil or paroxetine hydrochloride is another SSRI medication that is used to treat a wide variety of mental health conditions including anxiety, OCD, panic disorder, depression, post-traumatic stress disorder, and premenstrual dysphoric disorder. 

Paxil Reviews 

From drugs.com, here are user reviews of Paxil 

11/5/19

“After years and years of trying and failing with different medications, my doctor finally recommended paroxetine for my anxiety. No side effects unless I DON’T take it, no groggy feeling or haze over my memories anymore. I can function without feeling tired out half way through the day, I don’t get dry mouth, I don’t gain weight on this medication. All of which have been an issue with other meds in the past. Im very grateful to have found this.”

10/10/19

“Resisted taking any antidepressant for my anxiety Started paroxetine in July/ 10 MG, 2 -3 weeks. Stopped due to side effects. Restart in Aug, (4 weeks) at 5 mg. Quit again due to I got hyper. Restart again, slowly increase dose 2.5 to 5 mg work up to 10 mg. Dr. say I need antidepressant. I get panic attack and OCD. I had death in family in March. It may relieve OCD and lessen Panic. But I got very dizzy In past. One vertigo attack I fell over. Still assessing if it’s for me.”

8/29/19

“Paxil literally saved my life. Each person is individual and will react to antidepressants in a different way. I was on Paxil for 17 years and then I started to feel some major fatigue. I went off Paxil and didn’t have side effects. I have also tried Zoloft (zombie effect), effexor 75mg (worked on depression and anxiety but caused apathy), Fluoxetine 40mg (caused SI and had to be readmitted to hospital to get off it. I am now starting Paxil again after a year off it. This time around I have slowly increased from 20 to 30 to 40mg. It is one month since starting again. SI has gone. Mood is 80 percent. I still have some anxiety. I take Melatonin 10mg and Seroquel 12.5 to help with insomnia which I have never had before. I take 0.5 Risperidone in the morning to help with anxiety. I have lost 10kg and food is of no interest. I will keep you updated after a couple of months. Hopefully the fatigue doesn’t reoccur. Paxil is a great medication if it suits you.”

Celexa

Celexa, also known by the generic name citalopram is an SSRI that is most commonly prescribed to treat depression. 

Celexa Reviews 

From drugs.com, here are user reviews of Celexa 

11/8/19

“Celexa was prescribed for me after cancer treatments and it has made the most positive difference in my life. I feel alive again.”

11/1/19

“I’m 23 years old & began to have severe GAD due to a stressful situation. I felt worthless, depressed, anxious, & pessimistic. I decided to go to my doctor & was prescribed Celexa. I experienced a low appetite, insomnia , & mild diarrhea the first couple weeks. I also had increased mood swings. The adjustment period was rough! However, after about 6-8 weeks I started to level out & had less anxiety. Now I can say that my anxiety is about 90% cured! I have been taking this medicine for about 2-3 months. I still experience some anxiety during normal moments that I should experience some anxiety, but it’s NOTHING compared to where I used to be. I can still feel my emotions, the lows are just not as low anymore . I’m going through a break up right now & I can honestly say that although I’ve had sad moments I am still fully functioning & I am still managing to be happy with my life. Thank you Celexa!”

10/7/19

“I have been on this for 3 months and it still Hasn’t worked at all for me and I’m on 20mg of it.”

Tricyclic vs. SSRI Medications

The most commonly prescribed groups of antidepressants are SSRIs. However, there are some less commonly prescribed antidepressant drugs, called tricyclic antidepressants. 

Here’s how they are different. 


SSRIs: SSRIs stands for selective serotonin reuptake inhibitors. Reuptake is a process where neurotransmitters are reabsorbed in the brain through nerve cells. When taking an SSRI, this reuptake process is inhibited, and the neurotransmitter, serotonin, stays in the synapse (the gap between your nerve cells). The whole concept is that when neurotransmitter levels are higher, it may help support better communication between nerve cells, and thus help give the brain a boost to support a more balanced overall mood. 


Tricyclic: One of the oldest classes of antidepressant drugs, tricyclic antidepressants are believed to increase norepinephrine and serotonin. However, they are thought to come with more serious side effects and aren’t prescribed as often as SSRI medications. 


Taking Care of Your Mental Health is Just as Important as Your Physical Health 

Supporting your mental health is a huge part of supporting your overall health and wellness. Don’t neglect your mental health. If you are suffering from anxiety, depression, or have signs and symptoms of any other mental health condition, speak with a doctor, and make your mental health a priority. There are treatment options out there that can help. And always remember you are not alone.


Research shows that globally one in four people will have a mental health disorder at some point in their life.


Finding the Right Antidepressant For You 

It’s important to note that different medications work for different people. There is no one single antidepressant that works for everyone, which is why it’s so important to work with your doctor to create a custom treatment plan. 

By speaking with your doctor about your symptoms, prior and present medication history, and any other medications you are currently taking, your doctor can help you decide which option is best for you. 

How to Get an Antidepressant Prescription Online 

With the increased demand for digital healthcare, it’s easier than ever to get an antidepressant prescription online. With PlushCare’s online telehealth services, you can speak with a world class doctor as soon as today to discuss your concerns and talk about which antidepressant may work best for your individual needs. 


Click here to book an appointment today. 


Depression Quiz

The following 20 questions are pulled from an official depression test created by the Psych Central Research team. They have been carefully selected to ensure a comprehensive look at your mental health and specifically determine any symptoms of depression. When taking this test analyze your emotions from the past week.

I do things slowly.
I'm hopeless about my future.
I have trouble concentrating.
I feel that pleasure and joy has left my life.
I struggle to make decisions.
I have lost interest in things that used to be important to me.
I'm sad and unhappy.
I'm agitated and keep moving around.
I'm fatigued and it takes great effort for me to do simple tasks.
I feel I am a guilty person and deserve punishment.
I feel like a failure.
I feel lifeless.
My sleeping pattern has changed, I either sleep too much or too little.
I fantasize about suicide.
I plan how I might kill myself.
I feel trapped or caught.
I feel depressed even when good things happen to me.
Good things happen to me.
Without dieting I have lost or gained weight.
I feel alone, no one is there for me.

Read More About Antidepressants

References

World Health Organization. Mental Health Disorders Affect One In Four People. Accessed November 27, 2019 at https://www.who.int/whr/2001/media_centre/press_release/en/

Drugs.com. User Reviews Zoloft. Accessed November 27, 2019 at https://www.drugs.com/comments/sertraline/zoloft.html

Webmd. How Different Antidepressants Work. Accessed November 27, 2019 at https://www.webmd.com/depression/how-different-antidepressants-work#2

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